Alpha ,-adrenergic receptor

Some of the side effects due to beta blockers such as the slowing of heart rate can be counteracted by administration of drugs which antagonize the alpha adrenergic receptors. The... [Pg.19]

Antagonism of several characteristic effects of amphetamine and cocaine by the alpha adrenergic receptor antagonist prazosin is a most recent example of noradrenergic mechanisms in the actions of psychomotor stimulants (Tessel and Barrett 1986). We investigated whether or not prazosin may attenuate the disruptive effects of amphetamine on social and aggressive behavior in mice and squirrel monkeys (Miczek, unpublished observations). Pretreatment with prazosin (0.4 mg/kg) attenuated the disruption of attack... [Pg.85]

Fig. 5.12 (a) Synaptic types along dendritic spines of M/T and GC units uni-, and bi-directional junctions, (b) Transmitter systems at a reciprocal synapse, Mitral-Granule cell junction. [Glu, glutamate (R, receptor) GABA, y-aminobutyric acid (R, receptor) E, intracellular effector and aAR, alpha-adrenergic receptor.]. (From Hayashi et al., 1993.)... [Pg.121]

Spengler, R.N. et al., Stimulation of alpha-adrenergic receptor augments the production of macrophage-derived tumor necrosis factor, J. Immunol., 145, 1430, 1990. [Pg.504]

Prazosin volume, thereby reduces cardiac output Alpha-adrenergic receptor antagonist, inhibits symphathetic... [Pg.41]

Pharmacology Initially, clonidine stimulates peripheral -adrenergic receptors producing transient vasoconstriction. Stimulation of alpha-adrenergic in the brain stem results in reduced sympathetic outflow from the CNS and a decrease in peripheral resistance, renal vascular resistance, heart rate, and blood pressure. Pharmacokinetics Blood pressure declines within 30 to 60 minutes after an oral... [Pg.554]

Olanzapine High — serotonin 5-HT2a. 5-HT20 dopamine D-, D2, D3, D4, muscarinic M-, M2, M3, M4, M5, histamine H-, alpha- -adrenergic Weak— GABAa, benzodiazepine receptor, beta-adrenergic... [Pg.1094]

Lowe FC. Roie of the newer alpha,-adrenergic-receptor antagonists in the treatment of benign prostatic hyperplasia-related lower urinary tract symptoms. Clin Ther... [Pg.32]

Mechanism of Action An ocular alpha-adrenergic agent that is a relatively selective alphaj receptor agonist. Therapeutic Effect Reduces intraocular pressure. [Pg.84]

Mectianism of Action An antiadrenergic, sympatholytic agent that prevents pain signal transmission to the brain and produces analgesia at pre- and post-alpha-adrenergic receptors in the spinal cord. Therapeutic Effect Reduces peripheral resistance decreases BP and heart rate. [Pg.288]

Mechanism of Action An ergot alkaloid that centrally acts and decreases vascular tone, slows heart rate. Peripheral action blocks alpha-adrenergic receptors. Therapeutic Effect Improved Oj uptake and improves cerebral metabolism. Pharmacohinetics Rapidly, incompletely absorbed from GI tract. Metabolized in liver. Eliminated primarily in feces. Half-life 2-5 hr. [Pg.445]

Mechanism of Action An alpha-adrenergic agonist that stimulates alphaj-adrenergic receptors. Inhibits sympatheticcardioaccelerat or and vasoconstrictor center to heart, kidneys, peripheral vasculature. Therapeutic Effect Decreases systolic, diastolic blood pressure (BP). Chronic use decreases peripheral vascular resistance. Pharmacohinetics Well absorbed from gastrointestinal (GI) tract. Widely distributed. Protein binding 90%. Metabolized in liver. Excreted in urine and feces. Not removed by hemodialysis. Half-life 6 hr. [Pg.579]

Mechanism of Action An alpha-adrenergic receptor agonist that causes vasoconstriction, reflex bradycardia, inhibits GI smooth muscle and vascular smooth muscle supplying skeletal muscle and increases heart rate and force of heart muscle contraction. Therapeutic Effect Increases both systolic and diastolic pressure. [Pg.760]

Mechanism of Action An antihypertensive agent that stimulates central inhibitory alpha-adrenergic receptors, lowers arterial pressure, and reduces plasma renin activity. Therapeutic Effect Reduces BP. [Pg.784]

Mechanism of Action Exact mechanism is unknown. Appears to inhibit neuronal uptake of serotonin and norepinephrine and to antagonize alpha -adrenergic receptors. Therapeutic Effect Relieves depression. [Pg.853]

Mechanism of Action A sympathomimetic that stimulates betaj-adrenergic receptors and alpha-adrenergic receptors, increasing peripheral resistance. Enhances con-... [Pg.881]

Mechanism of Action A direct-acting sympathomimetic amine that acts on alpha-adrenergic receptors in arterioles of the nasal mucosa to produce constriction. Therapeutic Effect Causes vasoconstriction resulting in decreased blood flow and decreased nasal congestion. [Pg.926]

MecHanism of Action A sympathomimetic that directly stimulates alpha-adrenergic and beta-adrenergic receptors. Therapeutic Effect Produces vasoconstriction of respiratory tract mucosa shrinks nasal mucous membranes reduces edema and nasal congestion. [Pg.1052]

Geriatric Considerations - Summary Pseudoephedrine activates alpha-adrenergic receptors with the potential for CNS stimulation and increased blood pressure. Pseu-doephedrine causes increased urethral tone which would benefit stress incontinence but could cause urinary retention in older males with prostate hypertrophy. Older adults may have a greater sensitivity to the CNS effects of pseudoephedrine. [Pg.1054]

Mechanism of Action Adibenzothiazepinederivativethat antagonizes dopamine, serotonin, histamine, and alpha,-adrenergic receptors. Therapeutic Effect Diminishes manifestations of psychotic disorders. Produces moderate sedation, few extrapyra-midal effects, and no anticholinergic effects. [Pg.1064]

Mechanism of Action An antihypertensive and benign prostatic hyperplasia agent that blocks alpha-adrenergic receptors. Produces vasodilation, decreases peripheral... [Pg.1182]

Mechanism of Action A vasoconstrictor that stimulates alpha-adrenergic receptors in sympathetic nervous system. Constricts arterioles. Therapeutic Effect Reduces redness, irritation, and congestion. [Pg.1196]

Mechanism of Action An antipsychotic that blocks postsynaptic dopamine receptor sites in brain. Has alpha-adrenergic blocking effects, and depresses the release of hypothalamic and hypophyseal hormones. Therapeutic Effect Suppresses psychotic behavior. [Pg.1206]

Mechanism of Action A sympathomimetic that directly acts on alpha-adrenergic receptors in arterioles of the nasal mucosa to produce vasoconstriction resulting in decreased blood flow. Therapeutic Effect Decreased nasal congestion. Pharmacokinetics Onset of acf ion occurs wif hin 5-10 minuf es for a duration of action of 5-6 hours. Well absorbed fhrough nasal mucosa. May also be systemically absorbed from bofh nasal mucosa and gasfroinfesfinal (GI) fracf. Half-life Unknown. [Pg.1309]

Mecfianism of Action A piperazine derivative that antagonizes alpha-adrenergic, dopamine, histamine, and serotonin receptors also inhibits reuptake of serotonin and norepinephrine. Therapeutic Effect Diminishes symptoms of schizophrenia and depression. [Pg.1321]

It increases cerebral blood flow by blocking alpha adrenergic receptors. [Pg.121]

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