Neuromuscular blocking

C14H30CI2N2O4. White powder prepared from dimethylaminoethanol and succinyl chloride, followed by methylation. Neuromuscular blocking agent used to relax skeletal muscles during certain types of surgical operation. 

It is important to use these drag with caution in patients with a history of gastrointestinal disorders, renal disease, or liver impairment. The neuromuscular blocking action of die lincosamides poses a danger to patients widi myasthenia gravis (an autoimmune disease manifested by extreme weakness and exhaustion of die muscles). 

When kaolin or aluminum is administered widi die lincosamides, die absorption of the lincosamide is decreased. When the lincosamides are administered with the neuromuscular blocking drag (drag diat are used as adjuncts to anesthetic drag diat cause paralysis of the respiratory system) die action of die neuromuscular blocking drug is enhanced, possibly leading to severe and profound respiratory depression. 

Adverse effects of neuromuscular blocking agents 10 based on yellow card reporting in the UK. Are there differences between males and females Pharma-coepidemiol Drug Saf 2006 15 151. 

Baldo BA, Fisher MM, Pham NH On the origin and specificity of antibodies to neuromuscular blocking (muscle relaxant) drugs an immunochemical perspective. Clin Exp Allergy 2009 39 325. 

Pholcodine exposure raises serum IgE in patients 30 with previous anaphylaxis to neuromuscular blocking agents. Allergy 2007 62 1445. 

Mertes PM, Moneret-Vautrin DA Skin reactions to intradermal neuromuscular blocking agent injections a randomized multicenter trial in healthy volunteers. Anesthesiology 2007 107 245. Moneret-Vautrin DA, Gueant JL, Kamel L, Laxenaire MC, el Kholty S, Nicolas JP Anaphylaxis to muscle relaxants cross-sensitivity studied by radioimmunoassays compared to intradermal tests in 34 cases. J Allergy Clin Immunol 1988 82 745. 

Contrary to other elicitors of non-immune anaphylactic reactions (radiocontrast media, neuromuscular blocking agents, non-steroidal anti-inflammatory drugs (NSAIDs)) where there are at least hypothetical concepts regarding the pathomecha-nism of these reactions via increased mediator release (e.g. histamine release, shift in arachidonic acid metabolism from prostaglandins towards leukotrienes, etc.) [26], there is almost no literature regarding the pathomechanism of these reactions after LA application. 

Online detection using 4H nuclear magnetic resonance (NMR) is a detection mode that has become increasingly practical. In a recent application, cell culture supernatant was monitored on-line with 1-dimensional NMR for trehalose, P-D-pyranose, P-D-furanose, succinate, acetate and uridine.33 In stopped-flow mode, column fractions can also be analyzed by 2-D NMR. Reaction products of the preparation of the neuromuscular blocking compound atracurium besylate were separated on chiral HPLC and detected by 4H NMR.34 Ten isomeric peaks were separated on a cellulose-based phase and identified by online NMR in stopped-flow mode. 

Dunlap J, Brown JH. Heterogeneity of binding sites on cardiac muscarinic receptors induced by the neuromuscular blocking agents gallamine and pancuronium. Mol Pharmacol 1983 24 15-22. 

Colquhoun, D., On the principles of postsynaptic action of neuromuscular blocking agents, in New Neuromuscular Blocking Agents, Kharkevich, D. A., Ed., Springer-Verlag, Berlin/New York, 1986. 

Aminoglycosides Neuromuscular blocking agents Additive adverse effects Avoid... 

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