Neural prosthetics

Atddian M, Martin D (2005) CorrUolled Release of an Anti-Inflammatory Drug Usirrg Corrductirrg Polymer Narrotubes for Neural Prosthetic AppHcadorrs. hr MRS Symposium M, p 1. Sarr Francisco. 

Snyder, D.P. Repairing the Mind With Machines The Supernormal Possibilities of Neural Prosthetics. Omni. 15 (September 1993) 14. 

Berger, T.W. and Baudry, M., Brain-implantable biomimetic electronics as the next era in neural prosthetics, Proc. IEEE, 89, 7, 993, 2001. 

At present a few studies of nanofibers and nanombes are focused on CNS drug delivery. One study evaluated electrospun nanofibers of a degradable polymer, PLGA, loaded with antiinflammatory agent, dexamethasone, for neural prosthetic applications (Abidian and Martin, 2005). A conducting polymer, poly(3,4-ethylenedioxythiophene), was deposited to the nano-fiber surface and the coated nanofibers were then mounted on the microfabricated neural microelectrodes, which were implanted into brain. The drug was released by electrical stimulation that induced a local dilation of the coat and increased permeability. 

An Implantable Bionic Network of Injectable Neural Prosthetic Devices The Future Platform for Functional Electrical Stimulation and Sensing to Restore Movement and Sensation... 

Accurate histological reconstruction of recorded units is not possible due to the destruction inherent in placing it in the cortex and the trophic changes that take place as the tissue grows into the cone tip. This is not, however, of importance in neural prosthetics where functionality is paramount. 

Schuhnan, J., Mobley, R, Wolfe, J., Voelkel, A., Davis, R., and Arcos, I. An implantable bionic network of injectable neural prosthetic devices the future platform for functional electrical stimulation and sensing to restore movement and sensation. In Biomedical Engineering Fundamentals, Walker, C.F. and DiLorenzo, D.J. (eds). CRC Press, Boca Raton, FL, 2006, Chapter 34, pp. 34-1-34-18. 

Heetderks, W.). RF powering of millimeter- and submillimeter-sized neural prosthetic implants. 

J. Yang and D.C. Martin, Impedance spectroscopy and nanoindentation of conducting poly(3,4-ethylenediox)4hiophene) coatings on microfabricated neural prosthetic devices, J. Mater. Res., 21(5), 1124-1132 (2006). 

Neural recording/ Polymer sub- PPy Neural prosthetics 10-6M / (2007) George et al. 

Adhesive material can be used as sealant for minor dural defects while large dural defects require patches. In the case of minor dural defects, sutures or adhesives are used as dural sealants. However, suture alone are quick but do not provide adequate sealing of approximated tissue. The implantation of neural prosthetic devices such as deep brain stimulators and penetrating cortical electrodes for motor and... 

Kim, D-H., M. Abidian, and D.C. Martin. 2004. Conducting polymers grown in hydrogel scaffolds coated on neural prosthetic devices. / Biomed Mater Res 71A 577. 

G. E. Loeb, R. A. Peck, W. H. Moore, and K. Hood (2001), BION system for distributed neural prosthetic interfaces. Medical Engineering and Physics 23 9-18. 

Microelectronic implants have gained increasing interest in the bioengineering research community [19] and the medical device industry. Heart pacemakers are the most prominent example of an implantable microsystem that exhibits adaptive properties [20]. In the following section, adaptive properties of advanced pacemaker systems are described. Experience gained from heart stimulation devices has led to the development of a new class of implantable neural stimulators and sensor systems, namely neural prosthetic devices. More than a hundred thousand devices have been implanted in chn-ical practice, even though many applications are unknown to the general public [21,22]. Fabrication and the envisioned adaptive control mechanisms are described here upon. 

The business end of a neural prosthetic device is the electrode, the metal-tissue interface, through which the device is to do a job, safely and efficiently. Understanding how these electrodes operate will provide insight into the mechanisms of tissue injury and ways to extend their charge injection capacities. 

Neural prosthetic devices are artificial extensions of body parts which allow a disabled... 

Shain, W., Spataro, L., Dilgen, J., et al. (2003) Controlling cellular reactive responses around neural prosthetic devices using peripheral and local intervention strategies. IEEE Trans. Neural Syst. Rehab. Eng. 11, 186-8. 

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