Network structure supramolecular complexes

Here, we describe the design and preparation of antibody supramolecular complexes and their application to a highly sensitive detection method. The complex formation between antibodies (IgG) and multivalent antigens is investigated. When an antibody solution is mixed with divalent antigen, a linear or cyclic supramolecule forms [26-29]. With trivalent antigens, the antibody forms network structures. These supramolecular formations are utilized for the ampH-fication of detection signals on the biosensor techniques. 

Extracellular matrix (intercellular, pericellular matrix) is composed of a variety of polysaccharides and proteins that are spontaneously organized into ordered structures. It represents a supramolecular complex, formed by a network of molecules connected to each other [31,41]. In the human body, the extracellular matrix produces highly speciaUzed structures such as cartilage of the tendon, the basal membrane and after the secondary deposition of calcium phosphate, bones and teeth. Since these structures differ both in molecular composition and methods for organizing the main components, they comprise the various forms of the extracellular matrix [31,41]. Here we draw a generalized picture of the extracellular matrix and the functional role of hyaluronan in it. 

The silver(I) complexes with the tetrakis(methylthio)tetrathiafulvalene ligand have been reported, the nitrate salt presents a 3D structure with an unprecedented 4.16-net porous inorganic layer of silver nitrate,1160 the triflate salt presents a two interwoven polymeric chain structure.1161 The latter behaves as a semiconductor when doped with iodine. With a similar ligand, 2,5-bis-(5,5,-bis(methylthio)-l,3,-dithiol-2 -ylidene)-l,3,4,6-tetrathiapentalene, a 3D supramolecular network is constructed via coordination bonds and S"-S contacts. The iodine-doped compound is highly conductive.1162 (Methylthio)methyl-substituted calix[4]arenes have been used as silver-selective chemically modified field effect transistors and as potential extractants for Ag1.1163,1164... 

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