Antibody supramolecular

Here, we describe the design and preparation of antibody supramolecular complexes and their application to a highly sensitive detection method. The complex formation between antibodies (IgG) and multivalent antigens is investigated. When an antibody solution is mixed with divalent antigen, a linear or cyclic supramolecule forms [26-29]. With trivalent antigens, the antibody forms network structures. These supramolecular formations are utilized for the ampH-fication of detection signals on the biosensor techniques. 

Figure 10.11 Ru(ll) porphyrin 12 [57] and Rh(l) diphosphine complex 13 [58] used in antibody supramolecular assembly.

Keywords. Antibodies, Biosensors, Non-covalent bond. Atomic force microscopy, Supramolecular chemistry... 

Supramolecular Formation of Antibodies with Divalent Antigens 244... 

Applications for Highly-Sensitive Detection Method of Small Molecules by the Supramolecular Complexes between Antibodies... 

Somehow, Seebach ends his superb review, in which more than 500 references are quoted, with a rather optimistic message "that organic synthesis continues to react forcefully and with vitality to new challenges, still ready to pursue old dreams", and he refers to some exciting new targets such as supramolecular structures inhibitors, suicidal substrates and flustrates monoclonal antibodies and... 

Microtubules in the cytoskeleton and mitotic apparatus are also in a state of dynamic equilibrium and flux with unpolymerized tubulin, and tubulin appears to be an excellent example of the proteins which Pauling (1953) postulated to exist as globular protomers or as insoluble, fibrous, supramolecular structures akin to unpolymerized and polymeric hemoglobin S. The current view of the microtubule cytoskeleton in nondividing celb comes from the development of tubulin-specific antibodies for indirect immunofluorescent localization of microtubules (Fuller et al., 1975 Weber et al., 1975). The general structural features of such cyto-... 

The first examples of the so-called supramolecular catalysis are based on bioinspired molecular recognition, which is an essential attribute of biochemical systems. Structures such as receptors, antibodies, and enzymes can all recognize a feature that is important for their specific functions, often in the presence of species of quite similar structure. The ability to discriminate depends exclusively on the structural properties of these biological macromolecules. Recent progress in bioor-ganic chemistry has shown that many of these functions can be incorporated into smaller, synthetically more accessible structures as model systems [27]. 

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