Nervous system changes

Dean, B., Bradbury, R., and Copolov, D.L., Cannabis-sensitive dopaminergic markers in postmortem central nervous system changes in schizophrenia, Biol. Psychiatry, 53, 585, 2003. 

Acute Exposure If recovery from nerve agent poisoning occurs, it will be complete unless anoxia or convulsions have gone unchecked so long that irreversible central nervous system changes due to anoxemia have occurred. 

Central nervous system Changes in mood and behaviour Unknown... 

Gray F, Hurtrel M, Hurtrel B (1993) Early central nervous system changes in human immunodeficiency virus (HlV)-infection. Neuropathol Appl Neurobiol 19 3-9. 

Central nervous system changes are common with aging, including decreased cerebral blood flow, decreased cholinergic function, increased monoanune oxidase ac-... 

The clinical manifestations of hyponatremia are nonspecific weakness and apathy occur in mild cases, and central nervous system changes (lethargy, coma, and seizures) are present in more severe cases. No signs or symptoms are specific for SIADH. History, physical examination, and routine laboratory test results often suggest that hyponatremia is dilutional or depietional. 

Alzheimer s disease, autonomic nervous system changes, sudden death [73, 74]... 

Israeli R, Sculsky M, Tiberin P. 1983a. Acute central nervous system changes due to intoxication by Manzidan (a combined dithiocarbamate of maneb and zineb). Arch Toxicol Suppl 6 238-243. 

Israeli R, Sculsky M, Tiberin P. 1983b. Acute intoxication due to exposure to maneb and zineb A case with behavioral and central nervous system changes. Scand J Work Environ Health 9 47-51. 

The toxic threshold limit value as reported by Sax (Ref 3) ia ( pm in air or 750mg/m of air, and by Plunkett (Ref 8) is lOOppm and 375mg/m. Acute poisoning from the use of toluene is the result of a small amount of benz in commercial (coal-tar) derived toluene. Table 1 presents the effects of toluene vapor (Ref 4). Plunkett (Ref 8) reports that prolonged exposure to toluene vapor can result in permanent central nervous system changes such as cerebellar degeneration, tremulousness, ataxia, emotional lability and EEC changes... 

Central nervous system changes are the most frequently observed systemic toxicities of lidocaine. The initial manifestations are restlessness, vertigo, tinnitus, slurred speech, and eventually, seizures. Subsequent manifestations include CNS depression with a cessation of convulsions and the onset of unconsciousness and respiratory depression or cardiac arrest. This biphasic effect occurs because local anesthetics initially block the inhibitory GABAergic pathways, resulting in stimulation, and eventually block both inhibitory and excitatory pathways... 

Heart rate (HR), heart rate variability and blood pressure are regulated, in part, by the sympathetic and parasympathetic nervous systems. Changes in one or more may inerease the risk of cardiovascular events (e.g. arrhythmias, myocardial infarction). Decreases in heart rate variability have been associated with cardiovaseular mortality/morbidity in older adults and those with significant heart disease. Eine particles in ambient concentrations have recently been implicated in deereases of heart rate variability (Timonen et al. 2006), increased risk of arrhythmias (Metzger et al. 2004 Lanki et al. 2006) and increased blood pressure (Timonen et al. 2006) in particular in older subject with compromised health. Additionally inhaled particles seem to enhance blood coagulation (Riickerl et al. 2007a, b). 

In addition, the manifestations of dietary copper deficiency occur in animals that consume diets that contain copper antagonists, such as sulfide ion, molybdenum, zinc, silver, mercury, and cadmium (Evans, 1973). The extent and type of disorders associated with copper deficiency depend on species, age, sex, and severity of deficiency, but the disorders generally include anemia achromotri-chia lesions of the cardiovascular system, lung, skeleton, and central nervous system changes in the growth and appearance of hair, fur, or wool impaired growth and reproductive failure. 

The value of the skin potentials depends upon the activity of the sweat glands, cutaneous blood siqiply and tissue polarization it is regulated by the nervous system. Changes in skin potential and electrical conductivity are necessary components of the orienting reflex, and are investigated in the pharmacological analysis of this reflex. 

Eds.), Critical Care Clinics, vol. 21, Elsevier Inc., San Diego, CA, pp. 785-813. Cavanagh, J.B., Fuller, N.H., Johnson, H.R.M., et al., 1974. The effects of thallium salts, with particular reference to the nervous system changes. Quart. 

Properzi, F Asher, RA Fawcett, JW. Chondroitin sulphate proteoglycans in the central nervous system changes and synthesis after injury. Biochemical Society Transactions, 2003, 31, 335-336. 

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