Neonates body composition

To better understand changes in drug disposition, the pediatric population needs to be categorized into various groups (Table 1) because children vary markedly in their absorption, distribution, metabolism, and elimination of medications. This occurs because neonates, infants, children, adolescents, and adults have different body compositions (i.e., as to their percentages of body water and fat) and have their body organs in different stages of development. 

Huysman WA, de Ridder M, de Bruin NC, et al. Growth and body composition in preterm infants with bronchopulmonary dysplasia. Arch Dis Child Eetal Neonatal Ed 2003 88 F46-F51. 

Quantitative magnetic resonance (QMR) measurement of changes in body composition of neonatal pigs... 

The results of these studies demonstrate that QMR is a useful method for measuring changes in body composition in neonatal pigs. Furthermore, the results indicate that during the period of growth from birth to 4 kg, the rates of both fat and lean deposition are linear and highly correlated with... 

Fetal or neonatal brain prior to myelination contains relatively little cholesterol and in this respect the composition is similar to that of other body tissues. However, during this period before myelin is laid down, microscopic examination shows that small lipid droplets appear in variable number within the nervous tissue. In the human spinal cord droplets appear up to the twenty-second week of fetal life and in the chick embryo up to the sixteenth day of incubation. It would appear from histochemical reactions (Adams and Davison, 1959) that these droplets contain hydro-phobic lipids such as cholesterol esters or triglyceride. Chemical analyses... 

Fourteen neonatal male German Holstein calves were fed either eolostrum (C) or formula (F) for 4 days. Composition of colostrum and formula milk were in aeeordance with previous studies (Hammon et at, 2003 Scheuer et al, 2006). Calves were fed twice daily at 8% of body weight (BW) on day 1 and at 10% of BW from day 2 to 4. The morning meal on day 2 was divided in 10 half-hourly portions. During the interval feeding 5.7 pmol/kg BW -glucose was added... 

Greenwood, P.L., A.S. Hunt, J.W. Hermanson and A.W. Bell, 1998. Effects of birth weight and postnatal nutrition on neonatal sheep I. Body growth and composition, and some aspects of energetic efficiency. J Anim. Sci. 76, 2354-2367. 

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