Natural products chemopreventive activities

Ito, C. et al., Chemical constituents of Millettia taiwaniana structure elucidation of five new isoflavonoids and their cancer chemopreventive activity. Journal of Natural Products, 67, 1125, 2004. 

G., Moon, R. C., and Pezzuto, J. M., 1997, Cancer chemopreventive activity of resveratrol, a natural product derived lfom grapes, Science 275 218-220. 

Ito, C., Itoigawa, M., Miyamoto, Y., Onoda, S., Rao, K.S., Mukainaka, T., Tokuda, H., Nishino, H. and Furukawa, H. (2003a) Polyprenylated benzophenones from Garcinia assugu and their potential cancer chemopreventive activities. Journal of Natural Products 66(2), 206-209. 

Block, E., Birringer, M., Jiang, W., Nakahodo, T., Thompson, H. J., et al. Allium chemistry synthesis, natural occurence, biological activity, and chemistry of Se-alk(en)ylselenocysteines and their y-glutamyl derivatives and oxidation products. J Agric Food Chem 2001, 49, 458 470. Das, A., Desai, D., Pittman, B., Amin, S., El-Bayoumy, K. Comparison of the chemopreventive efficacies of l,4-phenylenebis(methylene)selenocyanate and selenium-enriched yeast on 4-(methylnitrosamino)-l-(3-pyridyl)-l-butanone induced lung tumorigenesis in A/J mouse. Nutr Cancer 2003, 46, 179-185. 

As part of a search for chemopreventive agents from natural products, nearly 400 plant extracts were tested for their potential to induce human promyelocytic leukemia (HL-60) cell differentiation. Seventeen of the plant extracts were active, with ED50 values of 4 pg/mL [139], One of most potent was an extract derived from Dirca occidentalis (Thymelaeaceae), which gave an ED50 of 0.14 pg/mL, and from it genkwanin, (+)-lariciresinol and sitoindoside II were isolated as active principles by a bioassay-guided fractionation. The ED50 values of the compounds were 18.3, 1.1 and 0.069 pM, respectively. 

Several natural products, such as curcumin, glycyrrhetic acid and P-carotin, have been well known as anti-tumor-promoters, and hereafter, many active compounds will be found out from natural resources. For the application of natural products to the chemoprevention, the inhibitory mechanism of them on chemical carcinogenesis is one of the most essential problem to be solved. 

Ciolino HP, Yeh GC (1999) Inhibition of aryl hydrocarbon-induced cytochrome P-450 lAl enzyme activity and CYPlAl expression by resveratrol. Mol Pharmacol 56 760—767 Clement MV, Hirpara JL, Chawdhury SH, Pervaiz S (1998) Chemopreventive agent resveratrol, a natural product derived from grapes, triggers CD95 signaling-dependent apoptosis in human tumor cells. Blood 92 996-1002... 

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