Benzophenones from Garcinia

Hussain, R.A. and Waterman, P.G. (1982) Lactones, flavonoids and benzophenones from Garcinia conrauana and Garcinia mannii. Phytochemistry 21 (6), 1393-1396. 

Ito, C., Itoigawa, M., Miyamoto, Y., Onoda, S., Rao, K.S., Mukainaka, T., Tokuda, H., Nishino, H. and Furukawa, H. (2003a) Polyprenylated benzophenones from Garcinia assugu and their potential cancer chemopreventive activities. Journal of Natural Products 66(2), 206-209. 

Thoison, O., Cuong, D.D., Gramain, A., Chiaroni, A., Hung, N.V. and Sevenet, T. (2005) Further rearranged prenylxanthones and benzophenones from Garcinia bracteata. Tetrahedron 61(35), 8529-8535. 

Rouz D, Hadi HA, Thoret S, Guenard D, Thoison O, Pais M, Sevenet T (2000) Structure-Activity Relationship of Polyisoprenyl Benzophenones from Garcinia pyrifera on the Tubulin/Microtubule System. J Nat Prod 63 1070... 

Hussain R A, Waterman P G 1982 Lactones, flavonoids and benzophenones from Garcinia con-rauana and Garcinia manii. Phytochemistry 21 1393-1396... 

Ito C, Itoigawa M, Miyamoto Y, Onoda S, Rao KS, Mukai-naka T, Tokuda H, Nishino H, Fumkawa H. Pol3fprenylated benzophenones from Garcinia assign and their potential cancer chemopreventive activities. J. Nat. Prod. 2003 66 206-209. 

Historically, reviews of benzophenones were included as small sections with the biogenetically related xanthones. Previous reviews include Bennett and Lee [1] who discussed the distribution and isolation of 20 benzophenones included in a review focused on xanthones. They also discussed the biosynthetic relationships between xanthones and benzophenones. Kumar and Baslas [2] summarized the chemical composition, medical importance, and biologically active benzophenones, biflavonoids, and xanthones isolated from Garcinia species. Two reviews by Waterman focused on the chemotaxonomic significance of benzophenones, along with biflavonoids and xanthones, of ten African Garcinia species [3,4], Locksley and Murray [5] discussed the distribution of thirteen benzophenones in higher plants and Sultanbawa [6] included five benzophenones in a review on xanthonoids from tropical plants. Sultanbawa also discussed the biosynthesis of benzophenones and xanthones. Erdelmeier et al. [7] discussed 20 polyprenylated benzophenones in a chapter on the various properties of St. John s Wort Hypericum perforatum). 

CjgHjoO, Mr 602.78, pale yellow needles, mp. 123-124 C, [alD -138° CHCI3). A wlyprenylated benzophenone derivative from Garcinia purpurea (Guttiferae) with remarkable antibacterial activity against methicillin-resistant Staphylococcus aureus (in vitro comparable with vancomycin). 

Minami, H. Hamaguchi, K. Kubo, M. Fukuyama, Y. A benzophenone and a xanthone from Garcinia subelliptica. Phytochemistry 1998,49, 1783-1785. 

Masullo M, Bassarello C, Suzuki H, Pizza C and Piacente S. 2008. Polyisoprenylated benzophenones and an unusual polyisoprenylated tetracyclic xanthone from the fruits of Garcinia cambogia. J Agric Food... 

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