Natural-product-based drug development programs

Hudson, J. Towers, G. H. N. Phytomedidnes as antivirals. Drugs Future, 1999,24 295-320. Yang, S. S. Cragg, G. M. Newman, D. J. Bader, J. P. Natural product-based anti-HIV drug discovery and development facilitated by the NCI developmental therapeutics program. J. Nat. Prod., 2001, 64 265 277. 

Yang SS, Cragg GM, Newman DJ, Bader JP (2001) Natural product-based anti-HIV drug discovery and development facilitated by the NCI development therapeutics program. J Nat Prod 64 265-277... 

After very successful drug discovery and development programs based on natural products, the pharmaceutical industry, in particular the large pharmaceutical companies, de-emphasized natural product discovery research in the 1990s and early This was caused by the advent of... 

Paclitaxel, camptothecin, vincristine, vinblastine, and other compounds currently under development as potential anticancer drugs (i.e., the bryostatins isolated from marine dinoflagellates) were discovered through a broad-based screening program to identify, using a whole-cell inhibition assay, natural products that are active against a battery of representative cancer cell lines. 

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