Developmental Therapeutics Program

The National Cancer Institute (NCI) database is a collection of more than half a million structures, assembled by NCI s Developmental Therapeutics Program (DTP) or its predecessors in the course of NCTs anti-cancer screening efforts that started in the late 1950s (plus the more recent anti-HIV screening) [37-39]. Approximately half of this database is publicly available without any usage restrictions, and is therefore called the "Open NCI Database. For each of these structures (more than 250 000) the DTP record contains at least the chemical structure as a coimection table and an NCI accession number, the NSC number. 

COMPARE Program. National Cancer Institute/National Institute of Health Developmental Therapeutics Program, http //dtp.nci.nih.gov/index.html... 

In some cases, compounds are purchased from laboratories or other suppliers. The collections of various compounds are called libraries, and libraries of large pharmaceutical organizations have from hundreds of thousands to millions of compounds. For example, the Developmental Therapeutics Program... 

This project has been funded in whole or in part with federal funds from the National Cancer Institute, National Institutes of Health, under Contract NOI-CO-I2400. The content of this publication does not necessarily reflect the views or policies of the Department of Health and Human Services, nor does mention of trade names, commercial products, or organization imply endorsement by the U.S. Government. This research was supported in part by the Developmental Therapeutics Program in the Division of Cancer Treatment and Diagnosis of the National Cancer Institute. 

David G. Covell, PhD Developmental Therapeutics Program, National Cancer Institute, Frederick, Maryland, USA... 

Shanker L. Gupta, PhD Pharmaceutical Research Branch Developmental Therapeutics Program Division of Cancer Treatment and Diagnosis National Cancer Institute National Institutes of Health Bethesda, Maryland... 

National Cancer Institute database (NCI 3D), dtp.nci.nih.gov (Developmental Therapeutics Program NCI/NIH). 

The isolation of the benzolactone enamide salicylihalamide A 17101 (Scheme 6.1 Part 2) was guided by the NCI s Drug Discovery Research and Development, Developmental Therapeutics Program screen for differential cytotoxicity, which showed that the Australian sample of Haliclona possessed a unique 60 cell line profile. Nanomolar potency was evident in the melanoma cell lines (GI50 = 7 nM) and a COMPARE analysis of the 60 cell line data indicated vascular ATPase (V-ATPase) activity potential. Further study of this structure class determined that salicylihalamide A is equipotent to the V-ATPase standards bafilomycin A and concanamycin A,273 but unlike these standards, selectively inhibits mammalian V-ATPases. 

Hudson, J. Towers, G. H. N. Phytomedidnes as antivirals. Drugs Future, 1999,24 295-320. Yang, S. S. Cragg, G. M. Newman, D. J. Bader, J. P. Natural product-based anti-HIV drug discovery and development facilitated by the NCI developmental therapeutics program. J. Nat. Prod., 2001, 64 265 277. 

Developmental Therapeutics Program Division of Cancer Treatment and Diagnosis... 

AWP —average wholesale price DTP —Developmental Therapeutics Program... 

National Cancer Institute, Laboratory of Molecular Pharmacology, Developmental Therapeutics Program, Division of Cancer Treatment, Bethesda, MD 20205... 

Our results were confirmed by independent studies carried out under the auspices of the Developmental Therapeutics Program National Cancer Institute (Table III). 

National Cancer Institute Division of Cancer TYeatment Developmental Therapeutics Program Drug Sjmthesis and Chemistry Branch... 

The discovery and development of anticancer drugs with clinical potential has been the responsibility of the Developmental Therapeutics Program (DTP), Division of Cancer Treatment, National Cancer Institute (NCI). In the mid-1980 s, approximately 10,000 compounds/year were selectively acquired and screened against murine (mouse) tumor models in order to discover new, active... 

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