Nasal drug delivery advantages

Interest in nasal drug delivery has grown unabatedly the last 15 years. This is due to the several advantages the nose presents with respect to drug delivery, some of which include [1] the following ... 

Although this section deals mainly with the advantages of excised tissues with respect to nasal drug delivery studies, it is important to highlight some important attributes of nasal in situ perfusion model. Although this method does not provide data on systemic absorption, it enables study of the interactions of nasal mucosal enzymes, peptide substrates, and metabolic inhibitors and their implications for nasal drug absorption [13], It also enables the rate of nasal drug absorption to be determined. 

List the advantages and disadvantages of nasal drug delivery... 

A brief overview of both the advantages and disadvantages of nasal drug delivery is given below. These can depend on the nature of the drag being delivered. 

Drug delivery via the nasal route offers a number of advantages, the most important of which is the possibility of needle-free treatment. It also means that—in addition to the newly developed peptide- and protein-based drugs—this method is also suitable for a wide variety and perhaps most of the drugs that are currently in use. However, it is not only convenience that sets nasal drug delivery apart This method also provides a rapid onset of action and high bioavailability. 

DirectHaler The DirectHaler (Direct-Haler A/S, Copenhagen, Denmark) nasal delivery device takes advantage of the nasal anatomy and an innovation in device technology in order to improve nasal drug delivery and patient compliance. Similar... 

As mentioned previously, one of the major benefits of nasal drug delivery is the rapid onset of action (tmax)- Migraine treatment takes advantage of this fact. Compared to the orally taken tablet, tmax is much shorter. The neurosecretory hormone melatonin, which is used widely against jetlag, shows a very impressive time profile when administered as a nasal spray. The peak levels of melatonin after nasal administration appear to be 50 times higher than after oral administration. 

In summary, the advantages of nasal drug delivery are as follows ... 

The nasal route is generating increasing interest as a route for the administration of local treatments and a cost-effective and patient-friendly alternative to injection for systemic delivery [49]. The special advantages of nasal delivery make it attractive for (i) crisis treatment where rapid onset of action is desirable (e.g., pain, migraine, panic attacks), (ii) systemic delivery of compounds that at present can only be delivered by injection (peptides/pro-proteins/vaccination), and (iii) direct targeting of the CNS (polar drugs for the treatment of CNS disorders). 

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