Naproxen interactions

Catalytic asymmetric hydrogenation was one of the first enantioselective synthetic methods used industrially (82). 2,2 -Bis(diarylphosphino)-l,l -binaphthyl (BINAP) is a chiral ligand which possesses a Cg plane of symmetry (Fig. 9). Steric interactions prevent interconversion of the (R)- and (3)-BINAP. Coordination of BINAP with a transition metal such as mthenium or rhodium produces a chiral hydrogenation catalyst capable of inducing a high degree of enantiofacial selectivity (83). Naproxen (41) is produced in 97% ee by... 

To enhance the removal of substances with high sorption properties, for example diclofenac (log = 2.7 and log A ow = 4.5. 8), ferric and aluminium salts may be added, increasing their removal rate to as much as 50-70% [66]. This strategy can also improve the removal of acidic compounds, for example naproxen, by ioiuc or chelating interactions [55]. 

On the column, the eluding liquid is important. The liquid must dissolve the desired compound but it should not be good of a solvent or it will inhibit the release of the desired molecule, allowing it to interact with the template cavity. In the case of naproxen, there is a further consideration. Naproxen has an acid function that was templated in the protonated form. Thus, acetic acid, along with THF and heptane, is added to insure that the naproxen is present in the needed correct geometry. 

Drug/Lab test interactions Naproxen use may result in increased urinary values for 17-ketogenic steroids. Temporarily discontinue naproxen therapy 72 hours before adrenal function tests are performed. 

Interaction of naproxen with the surfaces of silica gel and ODS silica gel HPLC packings. 

Useful for slightly more selective analyses of compounds containing large numbers of aromatic rings, e.g. propranolol and naproxen, where some additional interactions can occur with the phenyl groups on the stationary phase. These interactions are, however, very subtle... 

Only limited successful examples of asymmetric hydrogenation of acrylic acids derivatives have included the use of chiral Rh complexes (Scheme 1.17). The diamino phosphine (28) utilizes selective ligation of the amino unit to a Rh center and also exerts electrostatic interaction with a substrate. Its Rh complex catalyzes enantioselective hydrogenation of 2-methylcinnamic acid in 92% optical yield [116], Certain cationic Rh complexes can attain highly enantioselective hydrogenation of trisubstituted acrylic acids [ 1171. 2-(6 -Methoxynaphth-2 -yl)acrylic acid is hydrogenated by an (.S ..S )-BIPNOR- Rh complex in methanol at 4 atm to give (.S)-naproxen with 98% ee but only in 30% yield [26]. 

Diastereomeric complexes can also be formed by ion-pairing of an enantiomer with a chiral counterion. In order to form this diastereomeric complex, it has been postulated that at least three interaction points between the ion pair are required [250]. Nearly all of these form weak complexes in aqueous mobile phases. Consequently, the chromatographic methods that have been developed have been either silica or diol columns with low-polarity mobile phases. Enantiomeric amines, such as the beta-blockers, have been optically resolved when (-l-)-lO-camphorsulfonic acid was used as the chiral counterion [251]. Enantiomers of norephedrine, ephedrine, pseudoephedrine, and phenyramidol have all been resolved from their respective enantiomers with n-dibutyltartrate [252]. Enantiomers of naproxen, a chiral carboxylic acid, are resolved from each other by either using quinidine or quinine in the mobile phase [253]. In these studies, silica... 

Other compounds producing some inhibition of ZDV conjugation were oxazepam, salicylic acid, and acetylsalicyclic acid. More recently, Trapnell et al. examined the inhibition of ZDV at a more relevant concentration of 20 pM in bovine serum albumin (BSA)-activated microsomes by atovaquone, methadone, fluconazole, and valproic acid at therapeutically relevant concentrations (127). Both fluconazole and valproic acid inhibited ZDV glucuronidation by more than 50% at therapeutic concentrations. Clinical interaction studies have been conducted with methadone, fluconazole, naproxen, probenecid, rifampicin, and valproic acid (see Table 10). 

Runkel R, Mroszczak E, Chaplin M, et al. Naproxen-probenecid interaction. Clin Pharmacol Ther 1978 24(6) 706-713. 

In one study, there was a mean increase of only 17% in healthy volunteers taking celecoxib 200 mg bd (667). When celecoxib was co-administered with lithium, celecoxib concentrations were higher for the first 6 hours after the dose but the AUC was not altered significantly (668). In another review it was mentioned that clinically significant interactions with lithium (increased lithium concentrations) had been identified, but no detail was presented (669). Both celecoxib and naproxen reduced the renal clearance of lithium (used as a measure of proximal tubular sodium reabsorption) (670). 

Some NSAIDs (e.g, diclofenac, ibuprofen, naproxen, piroxicam) are actively metabolized by CYP2C9, which may be a site of possible interaction with inhibitors and inducers of this isoenzyme. 

Otero-Espinar, F.J. Anguiano-Igea, S. Garcia-Gonzalez, N. Vila-Jato, J.L. Blanco-Mendez, J. Interaction of naproxen with P-cyclodextrin in solution and in the solid state. Int. J. Pharm. 1992, 79 (2/3), 149-157. 

The FDA has announced its intention to require alcohol warnings on all over-the-counter pain medications that contain acetylsalicylic acid, salicylates, paracetamol, ibuprofen, ketoprofen, or naproxen. The proposed warnings are aimed at alerting consumers to the specific risks incurred from heavy alcohol consumption and its interaction with analgesics. For products... 

Naproxen Valproate Interaction of little or no clinical significance Displacement from plasma protein binding sites... 

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