Beta Naphthol

Hansen AM, Omland O, Poulsen OM, et al. (1994) Correlation between work process-related exposure to polycyclic aromatic hydrocarbons and urinary levels of alpha-naphthol, beta-naphthylamine and i-hydroxypyrene in iron foundry workers. Int Arch Occup Environ Health 65 385-394... 

Pigment Red 3 [2425-85-6] 12120 Beta-Naphthol (Toluidine Red) coupling of dia2oti2ed 2-nitto-4-methyl-aniline with 2-naphthol... 

Pigment Red 49, [1103-384] 15630 1 Beta-Naphthol (Ba salt) coupling of dia2oti2ed 2-amino... 

Beta-naphtol, n. beta naphthol, /3-naphthol (2-naphthol). -strahlen. m.pl. beta rays, betatigen, v.t. operate put into operation, start prove, manifest.—v.r. prove participate (in). 

Reaction conditions naphthalene = 15 g naphth/H Oj = 3 mole acetonitrile = 15 g reaction time = 8 h A= beta naphthol B = alpha naphthol C = naphthaquinones D = phthalic anhydride. 

For a general, simple high yield indole synthesis from anilines and methylthioacetaldehyde etc. see JACS 95,588,591,2718,6508 (1973). For indoles from N-( /3 -hydroxy-ethyl aniline esters see BSC 2485(1973). For a 2-acyl-indoles in one step from orthoamino-ketones and alpha-haloketones or 2-carboxyindoles from sulfonamides of ortho-aminocarbonyls see JOC 38,3622-24(1972). Indole and 5-Br-indole in 4 steps from beta-naphthol see Chem. Het. Cpds. (Russ.) 753(1973). Indole-JOC 37,3622(1972). 

In 1892, the chemist Schopf, in an attempt to prepare 2-phenylamino-3-naph-thoic acid, developed a synthetic route leading to the anilide of 2-hydroxy-3-naph-thoic acid. His method continues to be used today, if only in a slightly modified form. He added phosphorus trichloride to a molten reaction mixture containing aniline and 2-hydroxy-3-naphthoic acid (beta-oxynaphthoic acid, also known as BONA) and received Naphthol AS in good yield. Modern processes differ from this principle only in terms of reaction control the synthesis is now carried out in the presence of organic solvents, such as aromatic hydrocarbons. 

By using water-soluble organic solvents, usually referred to as precipitants, the reaction can be directed to produce only one cyclodextrin. In the presence of toluene, the enzyme from B. macerans produces only (3-cyclodextrin and linear starch chains. Beta-cyclodextrin can be separated from the soluble starch chains and recovered as a precipitated toluene complex. In the presence of decanol, a-cyclodextrin is the only cyclodextrin produced using the enzyme from B. macerans.21,22 Precipitants such as large cyclic compounds similar to musk oil23 or a-naphthol and methyl ethyl ketone (butanone)24 can be used to produce 8-cyclodextrin. 

Betol. Salol.— Another simple derivative of 6e/a-naphthol is the beta-naphthyl ester of salicylic acid analogous to oil of wintergreen, the methyl ester. It is another of the derivatives of this acid which has valuable medicinal properties. It is known as betol, also medicinally as salol. 

Naftazone (beta-naphthoquinone semicarbazone) is prepared by diazotization of sulfonic acid with beta-naphthol, and its properties are similar to those of... 

Figure 1. Strong anion exchange LC separation of phenols, aryl glucuronides and aryl sulfates using a UV absorbance detector. Compounds eluted are 1, phenol 2, 4-nitrophenol 3, 1-naphthol 4, phenyl-be ta-D-glucuronide 5, 4-nitrophenyl-beta-D-glucuronide 6, 1- naphthyl-beta-D-glucuronide 7, phenyl sulfate 8, 4-nitrophenyl sulfate 9, 1-naphthyl sulfate. (Reproduced with permission from Ref. 19. Copyright 1989 Elsevier Science Publishers B.V.)...

Benzyl phenyl acetate Benzyl phenyl ethyl ether Benzyl priopionate Benzyl salicylate Bensylidine acetone Beta naphthol isobutyl ether... 

Orange II made its appearance in 1876 and was obtained by coupling diazotized suiphanilic acid with beta naphthol... 

According to Weingart and Lancaster it is important to obtain a good pitch as the raw material e.g. the residue from the distillation of beta-naphthol, but the author does not find it easy to get this material at present. In Japan ordinary coal pitch is used but it has a defect for it produces much soot and smoke. There is another kind of snake named Pharaoh s Serpent. The composition contains a mercury compound and may be poisonous. 

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