Nanoparticles as drug carriers

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Nanoparticles have numerous applications in the chemical, food, pharmaceutical, biomedical and semiconductor industries. For example, nanoparticles as drug carriers can increase drug efficacy, and can reduce toxicity and side effect after parenteral administration (Feng et al., 2002). Nanoparticles used for industrial applications should have desirable physical properties, including appropriate size, surface charge, surface area, porosity and mechanical strength. The functionality of... 

Balthasar, S., K. Michaelis, et al. (2005). Preparation and characterisation of antibody modified gelatin nanoparticles as drug carrier system for uptake in lymphocytes. Biomaterials 26(15) 2723-32. 

Nanoparticles can be characterized by all the different physico chemical techniques that apply for polymer colloids. Concerning the development procedure of nanoparticles as drug carriers, the main physico chemical parameters that are investigated are the shape, the size, the surface properties, the density, and the concentration of the particles.f The size as well as the size distribution are important parameters to be determined to achieve safe intravenous administration. Surface properties are also important to consider as... 

Sanchez A, Alonso MJ. Nanoparticulate carriers for ocular drug delivery. In Torchilin VP, ed. Nanoparticles as Drug Carriers. Imperial College Press London 2006 649-673. 

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M.T. Chevalier, J.S. Gonzalez, and V.A. Alvarez, Polymeric micro and nanoparticles as drug carriers and controlled release devices New developments and future perspectives, in Advances in Materials Science Research. Vol. 17, M.C. Wythers, Ed., 2014, Nova Publishers. 

Wang JJ, Zeng ZW, Xiao RZ, Xie T, Zhou GL, Zhan XR, Wang SL. Recent advances of chitosan nanoparticles as drug carriers. Int J Nanomedicine. 6 765-774,2011. 

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