Nanomedicine

Recent advances in synthetic polymer preparation and formulation have enabled a rapid advancement of nanomedicine, with over 40 formulations being approved for routine human use in the last 20 years and many more currently in clinical development [6]. Examples include polymer-drug and protein conjugates [5], block copolymer polymeric micelles [7] and polyplexes developed for 

In 2001 Alivisatos, writing in Scientific American, identified several clinical targets for bionanotechnology [16]. As with conventional medicine there were two main threads diagnosis and therapy. Many existing and proposed applications of 

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By changing the ultrasound power, changes in the mesoporosity of ZnO nanoparticles (average pore sizes from 2.5 to 14.3 nm) have been observed. In addition to the changes in mesoporosity, changes in the morphology have also been noted [13]. Recently, Jia et al. [14] have used sonochemistry and prepared hollow ZnO microspheres with diameter 500 nm assembled by nanoparticles using carbon spheres as template. Such specific structure of hollow spheres has applications in nanoelectronics, nanophotonics and nanomedicine. 

Pinto Reis, C., Neufeld, R.J., Ribeiro, A.J., Veiga, F. and Nanoencapsulation., I. (2006) Methods for preparation of drug loaded polymeric nanopartides. Nanomedicine Nanotechnology, Biology, and Medicine, 2, 8—21. 

Nanomedicine and nanotoxicology two sides of the same coin. Nanomedicine, 1 (4), 313-6. 

Witzmann, A.F. and Monteiro-Riviere, N.A. (2006) Multi-walled carbon nanotube exposure alters protein expression in human keratinocytes. Nanomedicine, 2 (3), 158—168. 

Shvedova, A.A. and Kagan, V.E. (2010) The role of nanotoxicology in realizing the helping without harm paradigm of nanomedicine lessons from studies of pulmonary effects of single-walled carbon nanotubes. Journal of Internal Medicine, 267 (1), 106—118. 

Lacerda, L. et al. (2008) Tissue histology and physiology following intravenous administration of different types of functionalized multiwalled carbon nanotubes. Nanomedicine, 3 (2), 149—161. 

Moghimi, S.M. and Kissel, T. (2006) Particulate nanomedicines. Advanced Drug Delivery Reviews, 58 (14), 1451-1455. 

L. Lacerda, A. Bianco, M. Prato, and K. Kostarelos, Carbon nanotubes as nanomedicines From toxicology to pharmacology, Adv. Drug Deliv. Rev., 58 (2006) 1460-1470. 

Keywords Drug delivery Nanomedicine Nanoparticle PEGylated drug PEGylation... 

Oishi M, Nagasaki Y (2010) Stimuli-responsive smart nanogels for cancer diagnostics and therapy. Nanomedicine (Lond) 5 451 -68... 

Libutti SK, Paciotti GF, Byrnes AA, Alexander HR Jr, Gannon WE, Walker M, Seidel GD, Yuldasheva N, Tamarkin L (2010) Phase I and pharmacokinetic studies of CYT-6091, a novel PEGylated colloidal gold-rhTNF nanomedicine. Clin Cancer Res 16 6139-149... 

Several review articles focusing on the contribution of polymeric materials to nanomedicine have been published. This volume of Polymers in Nanomedicine in the series Advances in Polymer Science will be one of the pioneering review books dedicated to the study of polymer science for medical nanotechnology. 

I. Roy, T. Y. Ohulchanskyy, D. J. Bharali, H. E. Pudavar, R. A. Mistretta, N. Kaur and P. N. Prasad, Optical tracking of organically modified silica nanoparticles as DNA carriers a nonviral, nanomedicine approach for gene delivery, Proc. Natl. Acad. Sci. USA, 2005, 102, 279. 

Nanofiltration water desalination, energy consumption in, 26 87 Nanogold technology, 12 701 Nanoimprinting, optical, 15 193-195 Nano Indentor, 21 743 Nanoinhibitor design, 10 343 Nanomachines, 24 61-62 Nanomaterials, for sensors, 22 266 NanoMatrix, Inc., collagen nanofiber research, 1 723 Nanomedicine, 10 343... 

Bums AA, Vider J, Ow H, Herz E, Penate-Medina O, Baumgart M, Larson SM, Wiesner U, Bradbury M (2009) Fluorescent silica nanoparticles with efficient urinary excretion for nanomedicine. Nano Lett 9 442-448... 

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