Targeted Nanomedicine Systems

However, obtaining effective targeting in vivo remains a great challenge. Many studies that have been published have not achieved a statistically proven effect better than 

Farokhzad and co-workers, together with Danger and co-workers, have investigated the nse of nanoparticles based on poly(D,L-lactic-co-glycolic acid)-f -PEG in prostate cancer therapy for several years [73-76]. The Farokhzad group has recently prepared 

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Figure 11.1 Journey of a stimulus-targeted nanomedicine After intravenous administration, both stimuli-targeted and un-targeted nanomedicines rely on the EPR effect for primary tumor targeting. Then, activatable nanocarriers are converted in active forms by tumor stimuli, either acidosis, hypoxia or overexpressed proteases. This conversion leads to exposure of internalization moieties of pharmaceutical agent delivery systems or signal emission of enrichment nanoprobes. EPR enhanced permeabihty and retention effect, F fluorophore, Q quencher, MMP matrix metaUoproteases.

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