N-p-Methoxyphenyl

For imines, a-imino esters with an N-p-methoxyphenyl substituent (21b) also reacted with Danishefsky s diene in the presence of 10 mol% of CUCIO4-T0I-BINAP to give the corresponding adduct in high yield with good enantiomeric excess (Scheme 5.10). Remarkably, reverse enantioselectivity was observed when the a-imino esters 21a and 21b were used. This notable selectivity was explained by as-... 

The starting material for the above step may be prepared as follows 5 g (0.016 mol) of N -(p-methoxyphenyl)-p-chlorobenzhydrazide hydrochloride and 4.75 g (0.018 mol) of benzyl levulinoyloxyacetate were heated In 25 ml of glacial acetic acid for 3 hours at 80°C. The solvent was then evaporated off under vacuum. The residue was taken up in chloroform and the solution was washed neutral by shaking with sodium bicarbonate solution and thereafter with water. After drying the chloroform solution, this was subjected to chromatography on aluminium oxide, the eluate was concentrated by evaporation and the viscous oil remaining as residue was crystallized by adding ether. The compound melted at 94°-95 t. The yield was 4.1 g which corresponds to 50.7% of the theoretical yield. 

Asymmetric addition to ketimine in a reagent controlled manner has seldom been reported, even by 2008. When we investigated the potential for tbis asymmetric addition around 1992, there were no known examples. In 1990, Tomioka et al., reported the first asymmetric addition of alkyl lithium to N-p-methoxyphenyl aldo-imines in the presence ofa chiral (3-amino ether with 40-64% ee [8] (Scheme 1.11). In 1992, Katritzky reported the asymmetric addition of Et2Zn to in situ prepared N-acyl imine in the presence of a chiral (3-amino alcohol with 21-70% ee [15] (Scheme 1.12). In the same year, Soai et al., reported the asymmetric addition of dialkylzinc to diphenylphosphinoyl imines in the presence of chiral (3-amino alcohols with 85-87% ee [16] (Scheme 1.13). These three reports were, to the best of... 

Sparteine (11) catalyses efficiently the addition of organolithiums onto N-(p-methoxyphenyl)imines 455 (equation 124). Even substoichiometric amounts (e.g. 0.2 equiv.) of 11 gave good enantioenrichment. Alternatively, bis(oxazoline) ligands serve... 

Methyl Carbamate Formation via Modified Hofmann Rearrangement Reactions Methyl N-(p-Methoxyphenyl)carbamate. 

The procedure described here is based on a method outlined in U. S. patent 2,444,536.2 N-Phenylmaleimide has also been prepared by the dry distillation of the aniline salt of malic acid,5 4 by treating the aniline salt of malic acid with phosphorus pent-oxide,6 and by treating maleanilic acid with phosphorus trichloride or with phosphorus pentoxide.8 Ring-substituted N-phenylmaleimides, viz., N-(p-methoxyphenyl)-, N-(p-ethoxy-phenyl)-, and N-(/j-nitrophenyl)maleimide, have been prepared by treatment of the appropriate maleanilic acids with acetic anhydride and fused potassium acetate.7... 

Abbasi [234] has described a spectrophotometric method employing N-p-methoxyphenyl-2,-furohydroxic acid for the determination of titanium in soils. In this method, the soil sample was subjected to alkali fusion. The ash was treated with nitric acid to adjust it to pH 2.0 and filtered prior to adjustment to 10 pM with respect to hydrochloric acid. Stannous chloride (5M) was added to the filtrate, and the chromogenic reagent was dissolved in chloroform. The chloroform extract was evaluated spectrophotometrically at 385 nm against the reagent solution as blank. Approximately 61 ppm of titanium was found in a soil sample by this method. 

Selective extractive separation of antimony (usually Sbm), as well as selective complexation of Sbm (Mohammad et al., 1990), followed by hydride generation have been used for the determination of antimony in water. Four species of antimony in natural water have been identified Sbv, Sbm, methylantimony and dimethylantimony (Apte et al., 1986). The analyses were carried out using hydride generation cold trapping procedures. Sbm was separated from Sbv in natural and waste waters by extraction with N-p-methoxyphenyl-2-furylacrylohydroxamic acid into chloroform (Abbasi, 1989). The extracted antimony was determined by means of graphite-furnace AAS. The detection limit was 10 2mgdm 3. 

Abbasi, S.A. (1989) Sub-microdetermination of antimony (III) and antimony (V) in natural and polluted waters and total antimony in biological materials by flameless AAS following extractive separation with N-p-methoxyphenyl-2-furylacrylohydroxamic acid. Anal. Letts, 22, 237-255. 

S)-Proline has been used to catalyze Mannich-type reactions of enolizable carbonyl donors. Reactions of unmodified aldehydes and N-p-methoxyphenyl (PMP)-protected glyoxylate imine in the presence of a catalytic amount of (S)-proline at room temperature afforded enantiomerically enriched / -aminoaldehydes, as... 

An important application of oxidation of a C-H bond adjacent to a nitrogen atom is the selective oxidation of amides. This reaction proceeds in the presence of ferf-BuOOH as the oxidant and Ru(II) salts. Thus in the example of Eq. (36), the a-tert-butylperoxy amide of the isoquinoline was obtained, which is an important synthetic intermediate for natural products [138]. This product can be conveniently reacted with a nucleophile in the presence of a Lewis add. Direct trapping of the iminium ion complex by a nudeophile was achieved in the presence of trimethylsilyl cyanide, giving a-cyanated amines as shown in Eq. (37) [45]. This ruthenium/peracid oxidation reaction provides an alternative to the Strecker reaction for the synthesis of a-amino acid derivatives since they involve the same a-cyano amine intermediates. In this way N-methyl-N-(p-methoxyphenyl) glycine could be prepared from N,N-dimethyl-p-methoxyaniline in 82% yield. 

For the preparation of 4-(1.2.3.4-tetrahydroquinolino)-phenol 17 three different procedures were worked out [Eqs. (6)-(8)]. 17 was prepared by reacting N-p-methoxyphenyl-anthranilic acid with acetic anhydride and subsequent saponification to l-p-methoxyphenyl-4-hydroxy-2-quinolone, reaction withPOCl3 to form l-p-methoxyphenyl-4-chloro-2-quinolone, hydrogenation to l-(p-methoxy-phenyl)-3.4-dihydro-2-quinolone, splitting the ether with HBr to l-(p-hydroxy-phenyl)3.4-dihydro-2-quinolone, and reduction with LiAlH4 [Eq. (6)J. Another synthetic possibility was the reaction of p-anilinophenol with (3-propiolactone and subsequent cyclization to l-(p-acetoxyphenyl)2.3-dihydro-4-quinolone 18. The next step, the Wolff-Kishner reduction, led directly to the desired product [Eq. (7)]. The third way, the direct amination of p-iodoanisole with 1.2.3.4-tetrahydro-quinoline and the subsequent splitting of 4-(1.2.3.4-tetrahydro-quinolino)-anisol with HBr was the best one [Eq. (8)]. Saponification of l-(p-acetoxyphenyl>2.3-... 

N-(p-METHOXYPHENYL)-l-AZIRIDINECARBOXAXnDE see MFF250 p-METHOXYPHENYLBUTANONE see MFF580 4-P-METHOXYPHENYL-2-BUTANONE see MFF580 4-(p-METHOXYPHENYL)-2-BUTANONE see MFF580 p-METHOXYPHENYL-N-CARBAMOYLAZIRIDINE see MFF250... 

AES = atomic emission spectrometry Bq = Bequerel ICP = inductively coupled plasma (spectrometry) MHFA = N-p-methoxyphenyl-2-furylacrylohydroxamic acid MS = mass spectrometry NAA = neutron activation analysis OES = optical emission spectrometry... 

Abbasi SA. 1989. Atomic absorption spectrometric and spectrophotometric trace analysis of uranium in environmental samples with N-p-methoxyphenyl-2-furylacrylohydroxamic acid and 4-(2-pyridylazo) resorcinol. Intern J Environ Anal Chem 36 163-172. 

C13H14N20 N-(p-methoxyphenyl)-p-phenylenediamine 101-64-4 25.00 1.1289 2 26152 C13H17N302 5-butyl-2-benzimidazolecarbamic acid methyl 14255-87-9 25.00 1.1600 2... 

METHYL CARBAMATE FORMATION VIA MODIFIED HOFMANN REARRANGEMENT REACTIONS METHYL N-(p-METHOXYPHENYL)CARBAMATE (Carbamlc acid, (4-methoxyphenyl)-, methyl ester)... 

To a 1-L, round-bottomed flask equipped with a stirring bar are added p-methoxybenzamide (10 g, 66 mmol), N-bromosuccinimide (NBS) (11.9 g, 66 mmol), 1,8-diazabicyclo[5.4.0]undec-7-ene (DBU) (22 mL, 150 mmol) and methanol (300 mL) (Note 1). The solution is heated at reflux for 15 min (Note 2), at which point an additional aliquot of NBS (11.9 g, 66 mmol) is added slowly. The reaction is allowed to continue for another 30 min (Note 3). Methanol is removed by rotary evaporation and the residue is dissolved in 500 mL of ethyl acetate (EtOAc). The EtOAc solution is washed with 6 N hydrochloric acid (HCI) (2 x 100 mL), 1 N sodium hydroxide (NaOH) (2 x 100 mL) and saturated sodium chloride (NaCI), and then dried over magnesium sulfate (MgS04). The solvent is removed by rotary evaporation and the product, methyl N-(p-methoxyphenyl)carbamate, is purified by flash column chromatography [50 g of silica gel, EtOAc / hexane (1 1)] to give a pale yellow solid (11.1 g, 93%), which is further purified by recrystallization from 500 mL of hexane (Note 4). Another... 

METHYL CARBAMATE FORMATION VIA MODIFIED HOFMANN REARRANGEMENT REACTIONS METHYL N-(p-METHOXYPHENYL)CARBAMATE. 

Abbasi SA. 1987. Trace analysis of vanadium in environment as its ternary complex with N-p methoxyphenyl-2-furylacrylohydroxamic acid and 3-(o-carboxyphenyl)-1-phenyltriazine-N-oxide. Anal Lett 20 1347-1361. 

Bose and coworkers have reported that the condensation of ethyl biomoacetate with a variety of imines can be completed in a few hours at room temperature by means of ultrasound activation. Oxidative removal of a N-(p-methoxyphenyl) group gave )V-unsubstituted P-lactams, which are useful intermediates in the preparation of p-lactam antibiotics (Scheme 18). 

N-Methyl-N-nitroso-N -nitroguanidine added at 22 to a mixture of an ethereal p-methoxyaniline soln. and water, worked up after the gas evolution has ceased N-(p-methoxyphenyl)-N -nitroguanidine. Y 92.5%.—The reaction time varies from several hrs. to several days depending on the amine and the solvent used. The more basic amines react faster. (F. e. s. A. F. McKay, Am. Soc. 71,1968 (1949).)... 

N-(p-Methoxyphenyl)-p-phenylenediamine, N-(4-Aminophenyl)-p-anisidine 1,4-Benzenediamitie, N-(4-methoxyphenyl)- EINECS 202-962-9 N-(p-Methoxy-phenyl)-p-phenylenediamine Variamine Blue Base. Us in nnanufacture of azoic dyestutfe. Crystals tup = 102° bpi2 = 238°. Hoechst AG. 

Mizaikoff, B. Lendl, B. (2002). Sensor Systems Based on Mid-infrared Transparent Fibers, In Handbook of Vibratkmal Spectroscopy, J. M. Chalmers P. R. Griffiths (Eds.), John Wiley Sons Ltd., ISBN 0471988472, Chichester Pippel, D. J. Weisenburger, G. A. Faibish, N. C. Beak, P. (2001). Kinetics and Mechanism of the (-)-Sparteine-Mediated Deprotonation of (E)-N-Boc-N-(p>-methoxyphenyl)-3-cyclohexylallylamine. Journal of the American Chemical Society Vol.123, pp. 4919-4927, ISSN 0002-7863... 

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