Benzyl levulinoyloxyacetate

The starting material for the above step may be prepared as follows 5 g (0.016 mol) of N -(p-methoxyphenyl)-p-chlorobenzhydrazide hydrochloride and 4.75 g (0.018 mol) of benzyl levulinoyloxyacetate were heated In 25 ml of glacial acetic acid for 3 hours at 80°C. The solvent was then evaporated off under vacuum. The residue was taken up in chloroform and the solution was washed neutral by shaking with sodium bicarbonate solution and thereafter with water. After drying the chloroform solution, this was subjected to chromatography on aluminium oxide, the eluate was concentrated by evaporation and the viscous oil remaining as residue was crystallized by adding ether. The compound melted at 94°-95 t. The yield was 4.1 g which corresponds to 50.7% of the theoretical yield. 

Altschul Ber. Dtsch. Chem. Ges. (BDCGAS) 25, 1849 (1892). preparation o/benzyl levulinoyloxyacetate ... 

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