N- dimethylamine

Brompheniramine maleate N-o-Bromobenzyl-(M,N -dimethylamine Bretylium tosylate... 

N-(2- [Ethoxy(methyl)phosphoryl]sulfanyl ethyl)-IV-isopropyl-N-methylpropan-2-aminium Iodide N-(2- [Ethoxy(methyl)phosphoryl]sulfanyl ethyl)-IV-isopropylpropan-2-aminium Chloride N-(2-Chloroethyl)dimethylamine N-(2-Chloroethyl)-N,N-dimethylamine N-(2-Hydroxyethyl)diethylamine N-(4-Oxy-3-methoxybenzyl)-8-methyl-6-nonenamide N-(Diethylamino)ethanol N-(Isopropyl)-2-propamine... 

Mix 0.25M substituted benzaldehyde, 0.3M nitroethane, 50 ml dry toluene and 5 ml n-butylamine (or other amine), and reflux 3 hours with a Dean-Stark trap (or prepare the nitro-propene as described elsewhere here). Add 50 g iron powder and 1 g FeCl3 optional) and reflux while adding 90 ml concentrated HCI over 3 hours. Reflux 1 hour more, add 2 liters of water and extract 3 times with ether, then dry and evaporate in vacuum (or steam distill until about 3.5 liters of distillate is obtained extract the distillate 3 times with toluene wash the toluene layers with 7 g NaHS03 in 225 ml of water, then 3 times with water and dry, evaporate in vacuum) to get the ketone. Mix 0.13M ketone, 28 g formamide (or dimethyl-formamide if the N.N-dimethylamine is desired) and 3 ml formic acid and heat at 160°. Add 3 more ml formic acid and heat 16 hours at 170-180° adding formic acid from time to time to keep the pH acid. Distill off the water formed (about 16 ml), cool and extract with 3X70 ml benzene. Distill off the benzene and reflux the residue 7 hours with 30 ml concentrated HCI. Chill, basify with 10% NaOH and extract with 3X70 ml ether. Dry and evaporate the ether in... 

Fig. 7 Proposed explanation for the regioselectivity in methoxylation of N-benzyl-N, N-dimethylamine [28].

Biuret triisocyanate-adduct of hexamethylene diisocya- Mobay Chem. Co. nate with water Dibutyltin dilaurate Dimethyl 2,5-bis(ethyl-hexanoyl peroxy)hexane Benzoyl peroxide Calcium naphthenate Lead naphthenate Cobalt naphthenate Zinc naphthenate N-benzyl-N,N,dimethylamine Copper chloride Ferric chloride N,N-(Dimethylaminoethyl)-morpholine -Caprolactone Hydorquinone Xylene... 

Due to the partial n character of the CN bonds which are, in fact, vinylogous forma-mide or amidine connections in keeping with the resonance formulae, different methyl shift values are observed for some N,N-dimethylamine groups. Moreover, one-bond carbon-proton coupling constants decrease from the end to the center of the polymethine chain. This is explained by CNDO/2 calculations, in which corrected bond orders and bond angles alternating between 125° (a, y, e) and 117.5° (/5, 5) are taken into account [343],... 

N-o-Bromobenzyl-N,N-dimethylamine (lOOg) and ethyl p-toluenesulfonate (94 g) were mixed and warmed to 50°-60°C after standing for either (a) a minimum of 96 hours at 15°-20°C or (b) a minimum of 18 hours at 50°-60°C and cooling to room temperature, a hard, crystalline mass was formed. Recrystallization of this product from acetone (2.0 ml/g of crude solid), followed by filtration and drying to 60°C gave N-o-bromobenzyl-N-ethyl-N,N-dimethylammonium p-toluenesulfonate as a white, crystalline solid, MP 97°-99°C. For this procedure it was necessary that the reactants were substantially colorless and of a high purity. 

Groth, G., Schreeb, K., Herdt, V., and Freundt, K.J., Toxicity studies in fertilized zebrafish eggs treated with N-methylamine, N,N-dimethylamine, 2-aminoethanol, isopropylamine, aniline, N-methylaniline, N,N-dimethylaniline, quinone, chloroacetaldehyde, or cyclohexanol, Bull. Environ. Contamination Toxicol., 50, 878-882, 1993. 

BENZYL-3,3-a,4,5,6,6-a,9,10,12,15-DECAHYDRO-6,12,15-TRIHYDROXY-4,10,12-TRIMETHYL-5-METHYLENE-lH-CYCLOUNDEC(d)ISOINDOLE-l,ll(2H)-DIONE, 15-ACETATE see ZUSOOO BENZYL DICHLORIDE see BAY300 BENZYLDIMETHYLAMINE see DQP800 N-BENZYLDIMETHYLAMINE see DQP800 BENZYL-N,N-DIMETHYLAMINE see DQP800 BENZYLDIMETHYLAMINE METHIODIDE see BFM750... 

STILBENYL-N,N-DIMETHYLAMINE see DUB800 STILBESTROL see DKA600 STILBESTROL DIETHYL DIPROPIONATE see DKBOOO... 

Probably the most use has been made of the Eschweiler-Claike modification wherein formaldehyde is used together with formic acid to methylate amines." This procedure is especially useful for the clean preparation of N,N-dimethylamines, a particularly useful example being the N,N-dimethylation of amino acids. ... 

JP Dinnocenzo, SB Karki, JP Jones. On isotope effects for the cytochrome P-450 oxidation of substituted N,N-dimethylamines. J Am Chem Soc 115 7111-7116, 1993. 

Carbon suboxide, 52 Carbonylation, 148, 149, 216 Carbonyl chlorofluoride, 48, 54 Carbonyl cyanide, 60-61 N,N -Carbonyldiimidazole, 61 1,1-Carbonyldi-l,2,4-triazole, 61 N-Carbonylsulfamic acid chloride (N-Carbonylsulfamyl chloride), 61 Carboxamides, 270 Carboxamine-N-sulfochlorides, 70 p-Carboxybenzenediazonium chloride, 62 p-Carboxybenzenesulfonazide, 62 Carboxylation, 15, 16 Carboxylic acid anhydrides, 133 Carboxylic acid N,N-dimethylamines, 153 Carboxylic anhydrides, 409-410 p-Carboxyphenylhydrazones, 62 Cardenolides, 130, 131 (S-Carotene, 19 /-Carvone, 451, 452 i//-Caryophyllene, 149, 150 Catechol, 65, 233 Catechol amines, 159 Catechyl phosphorus tribromide, 63 Catechyl phosphorus trichloride, 63 Cis-Cecropia juvenile hormone, 261 Cedrene, 234, 235 a-Cedrene, 349 /3-Cedrene, 349 Cendranoxide, 234, 235 Cephalosporin C, 48 Ceric ammonium nitrate, 63-65 Ceric sulfate. 65 Cesium fluoride, 346 trans-Chalcone oxide, 422 Chalcone phenylhydrazones, 257, 258 Chalcones, 406 Chloramine, 65-66, 69 Chloranil, 66-67, 113, 116, 401,454... 

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