N,A -diphenyl

No oxidizing agent is required for the sulfuric acid promoted cyclization of N,A-diphenyl-hydroxylamine to carbazole (13CB3304). The parallel conversion of diphenyl sulfoxide and diphenyl selenoxide to dibenzothiophene (23CB2275) and dibenzoselenophene (39CR(l99)53l) is effected by treatment with sodamide. 

In vitro exposure of renal cortical slices to cephaloridine results in time- and concentration-dependent increases in lipid peroxidation, as reflected by malondial-dehyde production. Furthermore, the onset of cephaloridine-induced malondial-dehyde production preceded cephaloridine-induced inhibition of organic ion accumulation, suggesting that cephaloridine-induced lipid peroxidation mediates the effects of cephaloridine on organic ion transport. Additionally, antioxidants (e.g., promethazine, N, A -diphenyl-p-phenylenediamine) block the effects of cephaloridine on lipid peroxidation and on organic ion transport, suggesting a cause-effect relationship between cephaloridine-induced lipid peroxidation and inhibition of organic ion transport. 

The benzylic anion (175) generated from (174) reacted with N-a-diphenyl-nitrone (176) to give the phosphorate (177), characterized by P NMR, and subsequent protonolysis products. A similar reaction of the O-trans isomer of... 

First, a single HTL was used in a simple anode/HTL/ETL/cathode structure. Aromatic amines, N, A -diphenyl-fV, AE-bis(3-methylphenyl)-l, L-biphenylM, A-diamine (TPD),32 and TPAC31 were widely used. Instead of a single HTL as mentioned in Section 2.4, however, it was revealed that the formation of double HTLs, HTL-A, and HTL-E, as shown in Fig. 2.6 became indispensible for high-performance OLEDs. It is required that the Ip of HTL-A should be similar to that... 

Additionally, carbon radicals exhibit a high degree of energy, and few materials can effectively trap these intermediates. Diaryl-p-phenylenediamines such as N, A -diphenyl-p-phenylenediamine (Naugard J) and mixed diaryl-p-phenylenediamine (Novazone AS) are two examples of carbon radical traps. 

The N,]S7 - diphenyl- -phenylenediamine is prepared by heating hydroquiaone with aniline ia the presence of phosphoric acid (29). A[,Ar-di-2-naphthalenyl-/)-phenylenediamiQe is made from -phenylenediamine and 2-naphthol. 

Solubility. Another desirable property of a degradant is its high solubihty in mbber but poor solubihty in water and solvents that come in contact with mbber. Poor solubihty in the mbber means that only small quantities of antioxidants can be dissolved without producing a bloom. As an example, N,lSf-diphenyl- phenylenediamine (DPPD) has limited use because of its poor solubihty in mbber. On the other hand, phenohc and phosphite antioxidants have high solubihty and bloom is not a problem. 

When N,A/ -dimethyl-Af,N -diphenyl-p-phenylenediamine (231) underwent irradiation in die presence of oxygen, a remarkably regioselective reaction was observed, from which the /V,A/ -dimediylindolo[2,3-f ]carbazole (190) was obtained, without coformation of die other possible isomeric product, indolo[3,2-/)]carbazole (4). The expected intermediate 232, where only one ring closure had taken place, could not be detected. The authors attributed this fact to a two-photon autosensitization mechanism in which die conversion of 231 into 190 is sensitized by 232, permitting accumulation of 232 only in extremely small concentrations (83JA6268). 

Table 2.3 as a completely worked out example using quantitative solvent extraction, ash content determination, TGA, FTIR, XRF, GC-MS, HS-GC-MS, PyFTIR, ICP, and s-NMR. Information on the cure and antidegradant systems was obtained (assigned species/possible origin), as follows cyclohexane thiol/CBS accelerator benzothiazole/MBT, MBTS or CBS accelerators N, A-dimethylformamide/TMTD accelerator phthalim-ide/Santoguard PVI and IV-phenylbenzene amine/possi-bly a diphenyl/acetone amine antioxidant. 

Abb. 9 a u. b. a Diphenyl-trinitro-phenyl-hydrazyl b Picryl N-amino-carbazyl. 

The enantiomeric excesses of the phosphonic acid was measured using 31P NMR after treatment with (IS, 2S)-(—)-N,N -dimethyl(diphenyl-ethylene)-diamine in CDCI3 and a catalytic amount of CD3OD. 

Diethyl N,A(-diphenylaminomethylenemalonate (112, R = R1 = H)was heated in diphenyl ether at reflux temperature for I hr to give ethyl 1-phenyl-4-oxo-l,4-dihydroquinoline-3-carboxylate (559) in only 9% yield (69BRP1147336). For other N,/V-diarylaminomethylenemalonates, this procedure was completely unsuccessful. 

Products isolated from the thermal fragmentation of A-arylbenzamide oximes and A-arylbenzamide O-phenylsulfonyl oximes have been accounted for by invoking a free-radical mechanism which is initiated by the preferential homolysis of the N-O bond." Time-resolved IR spectroscopy has revealed that photolysis of A, A -diphenyl-l,5-dihydroxy-9,10-anthraquinone diimine affords acridine-condensed aromatic products via excited-state intramolecular proton transfer." The absolute and relative rates of thermal rearrangements of substituted benzyl isocyanides have been measured,and it has been found that the relative rates are independent of temperature and exhibit excellent Hammett correlations. Thionitrosoarene (25), thought to be generated by desulfurization of the stable A-thiosulfinylaniline (24), has been established" " as an intermediate in the formation of 3,3a-dihydro-2,l-benzisothiazole (26) from o-alkylthionitrosoarene (24). 

Metallation of malonaldehyde bis(phenylimine) hydrochloride with two equivalents of n-BuLi, in the presence of HMPA, yields lithium A,A -diphenyl-/3-diketiminate. The... 

C, A-diphenyl nitrones (p-XC6H4CHN(0)Ph, X = NO2, Cl, H, Me and MeO) with N-phenylmaleimide to form 2,3,6-triaryl derivatives of l-oxa-2,6-diazabicyclo[3.3.0]octane-5,7-dione. No enthalpy of formation data are available for A-phenylmaleimide or for maleimide itself. However, it is available for the corresponding A-methyhnaleimide along with some other imides. The gas phase enthalpy of hydrogenation of this species (derived as the difference between its enthalpy of formation and that of N-methylsucc-inimide ) is 133.7 2.2 kJmoC. This value is essentially the same as for ethylene (derived as the difference between its enthalpy of formation and that of ethane) of 136.3 0.4 kJmoH. Therefore, let us assume the reaction of the above parent nitrone with ethylene to form the diphenylated isoxazolidine, shown in equation 12, has very much the same exothermicity as with A-phenylmaleimide, namely ca 82 kJmol . If so, the enthalpy of formation of 2,3-diphenylisoxazolidine would be 233 kJmol . Now, is this value plausible ... 

Degradation of pentapropionyl-D-glucononitrile. (Sodium methoxide.Y - Five grams of pentapropionyl-n-glucononitrile was dissolved in 7 ml. of chloroform cooled to —6° and then a cool solution of 0.84 g. of sodium in 10 ml. of methanol was added. A jelly-like mass was produced that was kept in the ice-salt bath for five minutes. Fourteen milliliters of water and 2.5 ml. of acetic acid were then added. The water phase was separated and evaporated in vacuo 20 ml. of ethanol was added and the solvent evaporated again the operation was repeated once more. The final residue was dissolved in 26 ml. of water, and to 13 ml. 1 g. of diphenylhydrazine was added the solution was then heated in a water bath. When crystals of n-arabinose diphenyl-hydrazone appeared, heating was stopped, and after four hours in the cold the crystals were collected yield 54% (calcd. as n-arabinose), m. p. 204-205°. 

The preparation of the oily ethyl 2,3-diphenyl-5-methyl-isoxazolidine-4-carboxylate provides another example of this reaction. As in the procedure described with styrene, 10.0 g. (50.7 mmoles) of N,a-diphenylnitrone is heated under nitrogen for 24 hours at 90-100° with 35.0 g. (38.0 ml., 307 mmoles) of ethyl crotonate. The excess olefin, b.p. 45° (12 mm.) is removed on the water pump, and the red-orange residue, while still warm, is transferred to a 50-ml. Claisen flask using acetone as a rinse. 

A Michael type of addition is observed in the rection of N,N -diisopropyl-A,A -diphenyl-2,4-thiophenediamine (404) with DMAD to give the 1 1 adduct (405) [Eq. (61)].24 ... 

A solution of 12.6 g of methyl 4-(4-iodo-l-oxobutyl)-a,a-dimethylphenylacetate in 500 mL of toluene in a one liter three neck flask was added 8.8 g of 4-(a,a-diphenyl)piperidinemethanol and 23 g of K2C03 and the mixture was refluxed for 7 hours. The cooled reaction mixture was then filtered and concentrated in vacuo. The residue was dissolved in ether and treated with excess ethereal HCI. The mixture was then concentrated to a solid. The solid was treated with EtOAc and collected by filtration. The product was then partitioned between EtOAc and 2 N Na2C03. The organics were dried over MgS04, filtered, and concentrated in vacuo to afford 13.5 g (79%) of methyl 4-[4-[4-(hydroxydiphenylmethyl)-l-piperidinyl]-l-oxobutyl]-a,a-dimethylphenylacetate. 

Chemical Name 4-(4-Chlorophenyl)-4-hydroxy-N,N-dimethyl-a,a-diphenyl-1-piperidinebutanamide hydrochloride... 

A new base with a diphenyl linkage and two diphenyl ether links is tiliamosine, from Tiliacora racemosa, which has the structure (51 R1 = H, R2 = Me) the N-acetyl-nor-compound (51 R1 = COMe, R2 = H) has also been isolated and characterized.62... 

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