Myelin-oligodendrocyte-glycoprotein

In brief, EAE can be induced by immunization with several encephalitogenic proteins from myelin, most notably MBP, PLP and myelin-oligodendrocyte glycoprotein (MOG). MBP was the first protein shown to cause EAE, and this classical form of the disease is mediated primarily by CD4+, MHC class II restricted T cells, because it can be transferred from an immunized animal to a naive animal using these cells. These data document the importance of CD4+ lymphocytes for EAE induction, but additional pathogenic roles for other T cell populations are possible, especially in later stages of the disease. Also, there is... 

Iglesias, A., Bauer, J., Litzenburger, T. etal. T- and B-cell responses to myelin oligodendrocyte glycoprotein in experimental autoimmune encephalomyelitis and multiple sclerosis. Glia 36 220-234,2001. 

INSR insulin receptor MOG myelin-oligodendrocyte glycoprotein... 

Multiple sclerosis 58 64% myelin oligodendrocyte glycoprotein Infectious agents (Epstein-Barr virus), solvents, ultraviolet radiation/vitamin D, tobacco... 

Myelin Oligodendrocyte Glycoprotein (MOG) Peptide Fragment Rat (Sigma-Aldrich, MO, USA). 

Multiple sclerosis (MS) is the most frequent inflammatory demyeli-nating disease of the central nervous system that affects worldwide about 2.5 million people with no cure. Myelin oligodendrocyte glycoprotein-induced experimental autoimmune encephalomyelitis (MOG-induced EAE) in DA rats is an appropriate model for therapeutic testing, sharing many features with human multiple sclerosis. 

Stefferl, A., Schubart, A., Storch, M., Amini, A., Mather, I., Lassmann, H., Linington, C. 2000. Butyrophilin, a milk protein, modulates the encephalitogenic T cell response to myelin oligodendrocyte glycoprotein in experimental autoimmune encephalomyelitis. J Immunol. 165, 2859-2865. 

Johns TG, Bernard CC (1999) The structure and function of myelin oligodendrocytes glycoprotein. J Neurochem 72 1—9. 

Cofffey JC, McDermott KW. The regional distribution of myelin oligodendrocyte glycoprotein (MOG) in the developing rat CNS An in vivo immunohistochemical study. J Ncurocytol 1997 26 149-161. 

Linington C, Bradl M, Lassmann H, Brunner C, Vass K (1988) Augmentation of demyelination in rat acute allergic encephalomyelitis by circulating mouse monoclonal antibodies directed against a myelin/oligodendrocyte glycoprotein. Am J Pathol 130 443 54. 

Bruno R, Sabater L, Sospedra M, Ferrer-Francesch X, Escudero D, Martinez-Caceres E, Pujol-Borrell R (2002) Multiple sclerosis candidate autoantigens except myelin oligodendrocyte glycoprotein are transcribed in human thymus. Eur J Immunol 32 2737-2747. 

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