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Mycobacterium Steroids

Oxo-steroide 17-Oxo-steroide C orynebacterium simplex Mycobacterium globiforme Collagen Cellulose 2 Op - Hydroxy -stero ide 17p-Hydroxy-steroide H... [Pg.717]

Sitosterol is an abundant and low-cost raw material for the production of pharmaceutical steroids. 4-Androstene-3,17-dione, the precursor for the synthesis of corticosteroid hormones, can be derived from the side-chain cleavage of/3-sitosterol. Immobilized cells of Mycobacterium sp. NRRL B-3805 on Celite matrix (80-120 mesh) was found to be effective in cleaving the side chain of /3-sitosterol (5gL ) with a molar conversion yield of 70% in 50 h [30],... [Pg.236]

The derivatives 3-<9-methyl-D-olivose (D-oleandrose, 3-<9-methyl-2,6-dideoxy-D-arabino-hexose), and 3-0-methyl-D-oliose (3-<9-methyl-2,6-dideoxy-D-/yvo-hexose) are components of steroidal glycosides obtained from Cynanchum othophyllum Schneid, a traditional Chinese medicine.148 A derivative 4-O-me-thyl-D-olivose has been identified as the terminal sugar of the tetrasaccharide moiety in the phenolic glycolipid of Mycobacterium kansasii.149... [Pg.170]

Other products were 7(3-hydroxydigitoxin and 7(3-hydroxydigoxin. Microbial transformation of [16oc-3H]-precursors gave [16a-3H]androstenedione and [16a-3H]-oestradiol.244 It was reported that Tenebrio molitor was able to convert the 247 ,285-isofucosterol epoxide into cholesterol more readily than the 245,287 -isomer, whereas no significant difference was observed for the reactivities of the 24,28-fucosterol epoxides.245 Incubation of phytosterol mixtures with a mutant strain of Mycobacterium fortuitum resulted246 in the accumulation of novel 24-oxo-steroids... [Pg.328]

The cheapest of all sterols, however, is cholesterol, followed by ]3-sitos-terol. Both steroids have saturated side chains. Their chemical degradation is complicated and expensive and has no commercial value today. Biotechnology solved this problem. Fermentation with Mycobacterium phlei, Nocardia, or Arthrobacter in the presence of various inhibitors (e.g., nickel sulfate, cobalt chloride, 8-hydroxyquinoline) gives androstadiene-dione. From that point one can get anywhere in steroids by simple chemical modification. Only the degrada-... [Pg.140]

Many microbiol genera can degrade a variety of steroidal substrates to carbon dioxide and water (T-965 and references cited therein). This degradative ability is particularly prominent among the genera which dehydrogenate A -3-keto-steroids into the corresponding A compounds, such as Corynebacterium, Mycobacterium, Pseudomonas, and Nocardia. As a consequence, the production of the... [Pg.48]

Ouellet H, Guan S, Johnston JB, Chow ED, Kells PM, BurUngame AL, Cox JS, Podust LM, Ortiz de Montellano PR (2010) Mycobacterium tuberculosis CYP125A1, a steroid C27 monooxygenase that detoxifies intraeellularly generated eholest-4-en-3-one. Mol Mierobiol 77 730-742... [Pg.390]

Johnston JB, Ouellet H, Ortiz de Montellano PR (2010) Funetional redundancy of steroid C-26-mo-nooxygenase activity in Mycobacterium tuberculosis revealed by biochemical and genetic analyses. J Biol Chem 285 36352-36360... [Pg.390]

See other pages where Mycobacterium Steroids is mentioned: [Pg.430]    [Pg.308]    [Pg.320]    [Pg.342]    [Pg.280]    [Pg.279]    [Pg.386]    [Pg.243]    [Pg.255]    [Pg.344]    [Pg.219]    [Pg.67]    [Pg.300]    [Pg.67]    [Pg.716]    [Pg.288]    [Pg.308]    [Pg.320]    [Pg.22]    [Pg.308]    [Pg.320]    [Pg.430]    [Pg.504]    [Pg.504]    [Pg.67]    [Pg.308]    [Pg.67]    [Pg.833]    [Pg.132]    [Pg.145]    [Pg.534]    [Pg.409]    [Pg.46]    [Pg.23]   


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