Muscle gender differences

To investigate the hypothesis that differing mRNA levels underlie gender differences in the contractile response of the rat tail artery, a2-AR mRNA was measured using in situ hybridization. RNA for the a2A- and a2C-AR subtypes was localized to the smooth muscle layer. There was no detectable mRNA present for the a2B-AR subtype (50). 

Due to space limitations this subchapter cannot discuss the many reports of apparent gender differences of psychology, different anatomic brain location of functions, skeletal build and muscle-to-fat mass ratios which might have marginal impact upon drug activity. 

Serum creatinine is an amino acid compound derived from the metabolism of creatine in skeletal muscle and from dietary meat intake [35]. The serum creatinine concentration (Scr) is a commonly used marker for the estimation of adequate renal function due to the fact that it is released into the plasma at a relatively constant rate, is freely filtered by the glomerulus, and is not metabolized nor reabsorbed by the kidney. Various reference ranges for the Scr take into consideration differences in age and gender (Table 5), but fail to consider other variables such as race, body weight and muscle mass. As a result, a Scr within the reference... 

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