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Synthetic Muscarinic Receptor Antagonists

THE MODERN USES OF SYNTHETIC MUSCARINIC RECEPTOR ANTAGONISTS... [Pg.204]

The various applications of synthetic muscarinic receptor antagonists are listed in the following text. Ophthalmology... [Pg.204]

Propantheline bromide (Pro-banthine) resembles methantheline chemically (isopropyl groups replace the ethyl substituents on the quaternary N atom). Its pharmacological properties are also similar to those of methantheline, but it is two to five times more potent. It is one of the more widely used of the synthetic muscarinic receptor antagonists. Very high doses block the skeletal neuromuscular junction. The usual clinical dose (15 mg) acts for about 6 h. [Pg.207]

Over the past several decades with the ripening of the discipline of organic synthesis, man made compounds have been prepared which act on the fimctional unit of the muscarinic system which we now recognize as a receptor protein. Some of these have or remain to be used as therapeutic agents. More recently, the efforts of synthetic organic chemists have yielded muscarinic receptor antagonist ligands such as pirenzepine, AFDX-112, 4-DAMP, and... [Pg.27]

The class of drugs referred to as muscarinic receptor antagonists includes (1) the naturally occurring alkaloids, atropine and scopolamine (2) semisynthetic derivatives of these alkaloids, which primarily differ from the parent compounds in their disposition in the body or their duration of action and (3) synthetic congeners, some of which show selectivity for particular subtypes of muscarinic receptors. Noteworthy agents among the synthetic derivatives are homatropine and tropicamide, which have a... [Pg.694]

Propantheline bromide (pro-banthine) is a widely used synthetic nonselective muscarinic receptor antagonist. High doses produce the symptoms cf ganglionic blockade toxic doses block the skeletal neuromuscular junction. Its duration of action is comparable to that of atropine. [Pg.125]

This synthetic investigation confirmed the structure of the metabolite by comparison of fast atom bombardment-mass spectrometry (FAB-MS) spectra for the natural and synthetic cyclostellettamine C and for the monomeric synthetic compound 80 obtained by cyclization as indicated in Fig. (27). Additional confirmation came by comparing the bioactivities shown by synthetic dimer 55, mono-pyridinium 80 and natural cyclostellettamine C as antagonist agents for muscarinic receptors [43]. [Pg.371]

General Remarks BZ, also known as (1) QNB, (2) 3-quinuclidyl benzilate, and (3) benzilic acid, 3-quinuclidinyl ester, is a synthetic glycolic ester. Its medical action is as a competitive muscarinic cholinergic receptor antagonist, that is, an incapacitating agent. Like other such agents, its purpose is to produce temporary disability, not death (Wiener and Nelson, 2004). Indeed, the onset of symptoms may not appear until several hours after exposure. [Pg.40]

Takadoi M, Yamaguchi K, Terashima S (2003) Synthetic studies on himbacine, a potent antagonist of the muscarinic M2 subtype receptor. Part 2 synthesis and muscarinic M2 subtype antagonistic activity of the novel himbacine congeners modified at the C-3 position of lactone moiety. Bioorg Med Chem 11 1169-1186... [Pg.1362]


See other pages where Synthetic Muscarinic Receptor Antagonists is mentioned: [Pg.381]    [Pg.381]    [Pg.376]    [Pg.1796]    [Pg.191]    [Pg.330]    [Pg.531]    [Pg.712]    [Pg.1040]    [Pg.261]    [Pg.133]    [Pg.47]    [Pg.212]    [Pg.276]    [Pg.731]    [Pg.322]    [Pg.123]    [Pg.325]    [Pg.240]    [Pg.103]    [Pg.321]    [Pg.227]    [Pg.178]    [Pg.175]    [Pg.175]    [Pg.187]    [Pg.121]   
See also in sourсe #XX -- [ Pg.204 ]




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Muscarin

Muscarine

Muscarine receptors

Muscarines

Muscarinic

Muscarinic antagonists

Muscarinic receptors

Muscarinics

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