Muscarinic cholinergic receptors antagonists

Scopolamine A muscarinic cholinergic receptor antagonist that has amnesic side effects. 

General Remarks BZ, also known as (1) QNB, (2) 3-quinuclidyl benzilate, and (3) benzilic acid, 3-quinuclidinyl ester, is a synthetic glycolic ester. Its medical action is as a competitive muscarinic cholinergic receptor antagonist, that is, an incapacitating agent. Like other such agents, its purpose is to produce temporary disability, not death (Wiener and Nelson, 2004). Indeed, the onset of symptoms may not appear until several hours after exposure. 

Propantheline, a muscarinic cholinergic receptor antagonist, competitively blocks acetylcholine s actions at cholinergic neuroeffector sites, decreasing GI motility and inhibiting gastric acid secretion. 

Spinella M, Schaeffer LA, Bodnar RJ. (1997). Ventral medullary mediation of mesencephalic morphine analgesia by muscarinic and nicotinic cholinergic receptor antagonists in rats. Analgesia. 3 119-30. 

Worsening parkinsonism was observed in two patients after treatment with olanzapine 5 mg/day (114). In contrast, coarse tremors induced by fluphenazine or haloper-idol disappeared in three patients within days of the start of treatment with olanzapine (10 mg/day), without discontinuation or reduction in the dosage of fluphenazine or haloperidol (115). Olanzapine is active at muscarinic cholinergic receptors, which may account for the observed suppression of neuroleptic drug-induced tremor however, two of the three patients had been taking ben-zatropine, an antagonist at muscarinic acetylcholine receptors, with little tremor relief, suggesting that olanzapine could suppress tremor by means of an action other than muscarinic blockade. 

BZ, 3-quinuclinidinyl benzilate, is an antagonist at central and peripheral muscarinic cholinergic receptors. It produces both mental and physical incapacitation in humans. 

Eucatropine is a synthetic muscarinic cholinergic receptor antagoifist. The various applications of synthetic muscarinic receptor antagonists are listed below ... 

Tropane alkaloids are compounds known as muscarinic receptor antagonists. Atropine, its best-known member, and a number of other compounds, block the action of the neurotransmitter acetylcholine on post-ganglionic cholinergic nerves of the parasympathetic nervous system, essentially by blocking its binding to muscarinic cholinergic receptors, whereas they are much less potent at nicotinic receptor sites. 

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