Multifaceted problems

Looking at Figure 11.1, it is apparent that the pharmacokinetic optimization of drug candidates, or the assessment of risk posed by a chemical entity, is a complex, multifaceted problem. Generally speaking, there are three levels at which information is obtained and utilized. 

The examples shown above clearly illustrate the multifaceted problems related to the control of selectivity. It must also be added that, in principle, every organic compound is polyfunctional. Even methane, the simplest of organic molecules, can produce four dififerent products upon chlorination, from CH3CI to CCI4. Not surprisingly, the question of selectivity receives top... 

Naturally, the overall successful quantitative analysis is a multifaceted problem of sample choice, quantitative recovery during extractions and purification steps, choice of internal standards, signal recording technology, etc. Most of these topics are beyond the scope of this chapter, as they are not deemed to be particularly characteristic of biochemical GC. However, sample treatment prior to its introduction into a gas chromatograph will be the subject of a later discussion. 

No conclusion can adequately summarize the developments in the topic of this article. Host-guest chemistry is still in its infancy as a typical multidisciplinary subject. The progress in all basic disciplines will immediately provoke progress in the level of our knowledge on molecular complex formation by calixarenes. The synthesis of many new ligands and their thorough study will definitely be required to better understand the multifaceted problem of molecular recognition and complex formation. 

This problem is important since there are numerous problems of this kind and also because it underpins many techniques used for multifaceted problems. 

Systems engineering is a structured multidisciplinary approach to defining concepts and requirements for complex multifaceted problems that include conception, implementation, and validation. This is an ideal approach to developing solutions to clinical problems because they often involve more than one technical and clinical specialty. A concepts and requirements definition document creates a common interface that allows engineers and... 

GUI quality is a multifaceted problem. Two main aspiects can be identified. For the Human-Computer Interaction (HCI) practitioner the focus of analysis is on Usability, how the system supports users in achieving their goals. For the Software Engineer, the focus of analysis is on the quality of the implementation. Clearly, there is an interplay between these two dimensions. Usability will be a (non-fxmctional) requirement to take into consideration during development, and problems with the implementation will create problems to the user. 

The gradual move from green environments to deserts as a result of humanity-caused environmental dislocations is not a new phenomenon. Many old archeological sites have been unearthed in the Sahara desert, all over the Middle East, and in Takramakam. Desert areas have increased in just 1000 years. However, the deforestation that has been of reeent concern is due to increased meadowlands, sudden increases in population, reductions of forests to obtain fuel and fields, and abandonment of soil maintenance as a result of local conflicts. With such multifaceted problems, to what extent ean seience and technology, in particular polymer science, eontribute to reforestation It is perhaps difficult for reforestation to sueeeed onee the area is eompletely deforested. However, it is possible to produee vegetables in desert areas as well as to reproduce plants that help prevent deforestation. 

Events and causal factor analysis Use for multifaceted problems with long or complex causal factor chain Provides visual display of analysis process. Identifies probable contributors to the condition Time consuming and requires familiarity with process to be effective Requites a broad perspective of the event to identify unrelated problems. Helps to identify where deviations occurred from acceptable methods... 

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