Pharmacokinetic optimization

B. Testa, G. Cruciani, Structure-metabolism relations and the challenge of predicting biotransformation, in Pharmacokinetic Optimization in Drug Research, B. Testa, H. van de Water-beemd, G. Folkers, R. Guy (Eds.), WHey-VCH, Weinheim, New York, 2001, pp. 65-84. 

Cruciani G, Pastor M and Guba W. VolSurf a new tool for the pharmacokinetic optimization of lead compounds. Eur J Pharm Sci 2000 11 Suppl 2 S29-39. 

Testa, B., Van de Waterbeemd, H., Folkers, G., Guy, R. (eds.). Pharmacokinetic Optimization in Drug Research Biological, Physicochemical and Computational Strategies, VHGA, Zurich and Wiley-VGH, Weinheim, 2001. 

P., GuiUard, P., Carrupt, P.-A., Testa, B. Molecular hydrogen-bonding potentials (MHBPs) in structure-permeation relations. In Pharmacokinetic Optimization in Drug Research Biological,... 

Reymond, F., Gobry, V., Bouchard, G., Girault, H. H. Electrochemical aspects of drug partitioning. In Pharmacokinetic Optimization in Drug Research ... 

Figure 7.23 Relative acceptor compartment concentrations versus octanol-water apparent partition coefficients [550]. [Reprinted from Kansy, M. Fischer, H. Kratzat, K. Senner, F. Wagner, B. Parrilla, I., in Testa, B. van de Waterbeemd, H. Folkers, G. Guy, R. (Eds.). Pharmacokinetic Optimization in Drug Research, Verlag Helvetica Chimica Acta Zurich and Wiley-VCH, Weinheim, 2001, pp. 447-464, with permission from Verlag Helvetica Chimica Acta AG.]...

Faller, B., Wohnsland, F., Physicochemical parameters as tools in drug discovery and lead optimization, in Pharmacokinetic Optimization in Drug Research Biological, Physicochemcial and Computational Strategies. 

Figure 7. Lipophilicity profile of propranolol in liposomes composed of zwitterionic and charged lipids (phosphatidyl ethanolamine (PE), oleic acid (OA), phosphatidyl inositol (PI)). Conditions of measurements are described in [113]. The dotted line indicates the partitioning profile of propranolol in the egg PC liposome system. The bars show the pH-dependent charge profile of propranolol (hatched bars positively charged propranolol) and the lipids in the membrane (black bars negatively charged lipids). Reprinted from [113] Kramer, S. (2001). Liposome/water partitioning , In Pharmacokinetic Optimization in Drug Research, eds. Testa, B. et al. Reproduced by permission of Verlag Helvetica Chimica Acta, Zurich...

Kansy M, Fischer H, Kratzat K, Senner F, Wagner B, Parrilla I (2001) High-throughput artificial membrane permeability studies in early lead discovery and development. In Testa B, Van de Waterbeemd H, Folkers G, Guy R (Eds) Pharmacokinetic Optimization in Drug Research. Biological, Physicochemical and Computational Strategies. Wiley-Interscience, Hoboken, pp 447 -64. 

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