Multi-drug resistance-1 gene

Kioka, N., Hosokawa, N., Komano, T., Hiiayoshi, H., Nagat, K., Ueda, K. (1992). Quercetin, a bioflavonoid, inhibits the increase of human multi-drug resistance gene (MDRI) expression caused by arsenite. FEES Lett. 301, 307-309. 

PETERSON G and BARNES s (1991) Genistein inhibition of the growth of hiunan hreast cancer cells independence from estrogen receptors and the multi-drug resistance gene. Biochem Biophys Res Commun. 179 (1) 661-7. 

Hoffmeyer S, Burk O, Von Richter O, Arnold HP, Brockmoller J, Johne A et al. Functional polymorphisms of the human multi-drug resistance gene multiple sequence variations and correlation of one allele with P-glycoprotein expression and activity in vivo. Proc Natl Acad Sci USA 2000 97 3473-3478. 

This is known to be mediated in some instances by the multi-drug resistant gene (MDRl) producing the /J-glycoprotein, where /(-glycoprotein expression was associated with a decrease in intracellular IM levels and development of resistance (37). 

Zhao JY, Ikeguchi M, Eckersberg T et al. Modulation of multi-drug resistance gene expression by dexam-ethasone in cultured hepatoma cells. Endocrinology 1993 133 521-8. 

Fojo, A.T. Ueda, K. Slamon, D.J. Poplack, D.G. Gottesman, M.M. Pastan, M.M. Expression of a multi-drug-resistance gene in human tumors and tissues. Proc. Natl. Acad. Sci. USA 1987, 84, 265-269. 

P-glycoprotein (P-gp) is an ATP-dependent drug efflux pump. In humans, P-gp is encoded by the multi-drug resistance gene (MDR-1) that is located on the long arm of chromosome 7. Overexpression of P-gp in neoplastic cells is associated with the phenomenon of multidrug resistance to chemotherapeutic agents... 

Stewart J, Gorman NT. Multi-drug resistance genes in the management of neoplastic disease. J Vet Intern Med 1991 5 239-247. 

The first cloned sequences of the multi-drug resistance transporter (P-glycoprotein, MDR1, ABCB1) were isolated from multi-resistant cell lines in which the gene was strongly amplified. By in-gel renaturation analysis these... 

Augmented drug extrusion increased synthesis of the P-glycoprotein that extrudes drugs from the cell (e.g., anthracyclines, vinca alkaloids, epipodophyllotoxins, and paclitaxel) is re-ponsible for multi-drug resistance (mdr-1 gene amplification). 

Ueda, K., Cornwell, M.M., Gottesman, M.M., Pastan, I., Roninson, I.B., Ling, V. and Riordan, J.R. (1986) The MDR1 gene, responsible for multi-drug resistance, codes for P-glycoprotein. Biochemical and Biophysical Research Communications, 141, 956-962. 

ABCBl ATP-binding cassette family (ABC) Bl multi-drug resistance (MDRl) a human gene that encodes P-glycoprotein MRP multi-drug resistance protein ... 

Cole SP, Bhardwaj G, Gerlach JH, Mackie JE, Grant CE, Almquist KC, Stewart AJ, Kurz EU, Duncan AMV, Deeley RG. Overexpression of a transporter gene in a multi-drug-resistant human lung-cancer cell-line. Science 992-, 258 1650-1654. 

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