Mucosal antibodies

Rotavirus enterotoxin protein NSP4 fused to CTB Potato Fusion proteins assembled into cholera holo-toxin-like structures that retained enterocyte-binding affinity Orally immunized mice generated levels of serum and mucosal antibodies specific for the native antigen. Induced TH1 immune response. 63,64... 

Peng X, Cebra JJ, Adler MW, Meissler Jr JJ, Cowan A, Feng P, Eisenstein TK (2001) Morphine inhibits mucosal antibody responses and TGF-P mRNA in gut-associated lymphoid tissue following oral cholera toxin in mice. J Immunol 167 3677-3681. 

Shroff, K.E. Marcucci-Borges, L.A. de Bruin, S.J. Winter, L.A. Tiberio, L. Pachuk, C. Snyder, L.A. Satishchandran, C. Ciccarelli, R.B. Higgins, T.J. Induction of HSV-gD2 specific CD4(+) cells in peyer s patches and mucosal antibody responses in mice following DNA immunization by both parenteral and mucosal administration. Vaccine 1999,18, 222-230. 

Several studies in experimental animals and humans have demonstrated the immunostimulatory effects of lactic cultures on several aspects of humoral and cell-mediated immunity (Nader de Macias et al., 1992 Perdigon et al., 1990 Kaila et al., 1992). Whether the immunoenhancing effects of LAB are related to their immuno-genicity is not known. It is well documented that mucosal antibodies prevent the... 

Jones D H, Corris S, McDonald S, et al. (1997). Poly(DL-lactide-co-glycolide)-encapsulated plasmid DNA elicits systemic and mucosal antibody responses to encoded protein after oral administration. Vaccine. 15 814-817. 

H. pylori colonizes the stomach mucosa and defining immunogenic proteins with serum antibodies may not reveal relevant immunogenic proteins. IgA constitutes the major class of mucosal antibodies and... 

EdTx has been shown to act as a mucosal adjuvant, enhancing both systemic and mucosal antibody responses to ovalbumin (OVA) and inducing a mixed T helper (Th) 1/Th2 OVA-specific CD4 T response following intra-nasal co-administration, potentially related to its ability to induce AP-1 and C/EBP-P expression in murine macrophages. In contrast, EdTx inhibits murine CD4 T-cell proliferation and the production of IL-12 and tumour necrosis factor (TNF)-a by murine DC in response to B. anthracis spores. Additionally, both LeTx and EdTx have been shown to inhibit human neutrophil chemotaxis - and superoxide production. - ... 

Park SJ, Chun SK, Kim PH. Intrapcritoneal delivery of cholera toxin B subunit enhances systemic and mucosal antibody responses. Mol Cells 2003 16(1) 106-112. 

Dry powder nasal vaccine formulation Whole inactivated influenza virus Enhanced serum and mucosal antibody response [96]... 

LAFRENTZ, B.R., LAPATRA, S.E., JONES, G.R., CONGLETON, J.L., SUN, B. and CAIN, K.D. (2002) Characterization of the serum and mucosal antibody responses and relative per cent survival in rainbow trout, Oncorhynchus mykiss (Walbaum), following immunization and challenge with Flavobacterium psychrophUum. Journal of Fish Diseases 25,703-713. 

GRABOwsKi LD, LAPATRA SE, CADS KD. Systeiiiic and mucosal antibody response in tilapia, Oreochromis ndoticus (L.), following inununization with Flavobacterium columnare. J Fish Dis 2004,27,573-581. 

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