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Gastric Mucin

Most substances are not readily absorbed in the mouth or esophagus one of several exceptions is nitroglycerin, which is administered for certain heart disfunctions and absorbed if left in contact with oral tissue. The stomach is the first part of the gastrointestinal tract where substantial absorption and translocation to other parts of the body may take place. The stomach is unique because of its high content of HC1 and consequent low pH (about 1.0). Therefore, some substances that are ionic at pH values near 7 and above are neutral in the stomach and readily traverse the stomach walls. In some cases, absorption is affected by stomach contents other than HC1. These include food particles, gastric mucin, gastric lipase, and pepsin. [Pg.142]

Ishihara, K., Kameyama, J. -I., and Hotta, K., Development of an HPLC method to estimate hexosamines and its application to determine mucin content in rat and human gastric mucosa, Comp. Biochem. Physiol., 104B, 781, 1993. [Pg.282]

Another approach is that of bioadhesive materials. The principle is to administer a device with adhesive polymers having an affinity for the gastric surface, most probably the mucin coat [12]. Bioadhesives have demonstrated utility in the mouth, eye, and vagina, with a number of commercially available products. To date, use of bioadhesives in oral drug delivery is a theoretical possibility, but no promising leads have been published. [Pg.506]

Blood Group A carbohydrate (from saliva, pepsin, urine, gastric mucin, pancreas, etc.)... [Pg.181]

Only two mucoitin sulfates are well authenticated, one from gastric mucin and one from the cornea (hyaluronic acid sulfate). [Pg.201]

Bhaskar KR, Garik P, Turner BS, Bradley JD, Bansil R, Stanley HE, et al Viscous fingering of HC1 through gastric mucin. Nature 1992 360 458-461. [Pg.19]

Also, related structures reported in adult gastric mucin... [Pg.321]

Keratan sulfate (102-104), hen ovomucin (105), rat gastric mucins (106), porcine thyroglobulin (107) Recombinant tissue plasminogen activator expressed in mouse epithelial cells (108)... [Pg.329]

Fiebrig, L, Harding, S.E., Rowe, A.J., Hyman, S.C., and Davis, S.S., Transmission electron microscopy studies on pig gastric mucin and its interactions with chitosan, Carbohydr. Polym., 28 239-244 (1995). [Pg.189]

Gastric juice is the product of several cell types. The parietal cells produce hydrochloric acid, chief cells release pepsinogen, and accessory cells form a mucin-containing mucus. [Pg.270]

Effect on secretions Atropine reduces the various body secretions e.g. sweat, salivary, bronchial and lacrimal etc. It also reduces the volume and total acidity of gastric secretion and, reduce the secretion of mucin and enzymes in the gastric secretions induced by cholinergic drugs. [Pg.163]

Mammals have two isozymes of prostaglandin H2 synthase, COX-1 and COX-2. These have different functions but closely similar amino acid sequences (60% to 65% sequence identity) and similar reaction mechanisms at both of their catalytic centers. COX-1 is responsible for the synthesis of the prostaglandins that regulate the secretion of gastric mucin, and COX-2 for the prostaglandins that mediate inflammation, pain, and fever. Aspirin inhibits both isozymes about equally, so a dose sufficient to reduce inflammation also risks stomach irritation. Much research is aimed at developing new NSAIDs that inhibit COX-2 specifically, and several such drugs have become available. [Pg.802]

Caprine Antiserum Containing Antibodies to Two Antigenic Determinants on Type H Hog Gastric Mucin, J. Immunol. (1967) 99, 987. [Pg.368]

Porcine, gastric mucin Human, gastric mucin, and a-GlcNAc-(l- 4) -GlcN Ac-( l->4)-0-Gal-(l->4)-0-GlcNAc-( l- 6) 70... [Pg.167]


See other pages where Gastric Mucin is mentioned: [Pg.11]    [Pg.246]    [Pg.323]    [Pg.400]    [Pg.179]    [Pg.181]    [Pg.198]    [Pg.200]    [Pg.201]    [Pg.203]    [Pg.204]    [Pg.316]    [Pg.318]    [Pg.320]    [Pg.325]    [Pg.647]    [Pg.120]    [Pg.120]    [Pg.268]    [Pg.1359]    [Pg.42]    [Pg.48]    [Pg.55]    [Pg.430]    [Pg.432]    [Pg.159]    [Pg.25]    [Pg.802]    [Pg.163]    [Pg.154]    [Pg.352]    [Pg.362]    [Pg.362]    [Pg.366]    [Pg.167]    [Pg.21]   
See also in sourсe #XX -- [ Pg.724 ]




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