Gastric-type mucins

Hong SP, Lee EK, Park JY, et al. Cripto-1 overexpression is involved in the tumorigenesis of gastric-type and pancreatobiliary-type intraductal papillary mucinous neoplasms of the pancreas. Oncol Rep. 2009 21 19-24. 

Gastric juice is the product of several cell types. The parietal cells produce hydrochloric acid, chief cells release pepsinogen, and accessory cells form a mucin-containing mucus. 

Caprine Antiserum Containing Antibodies to Two Antigenic Determinants on Type H Hog Gastric Mucin, J. Immunol. (1967) 99, 987. 

The reaction of partially purified, lima-bean lectin with hog gastric-mucin type A substance exemplified the precipitin-like curve obtained for lectin-polysaccharide or -glycoprotein reactions.103 Classical precipitin-curves between purified components II and III and type A blood-group substance were also obtained.151,199 Maximal precipitation of component II (equivalence) occurred at a lower ratio of A substance per mole of protein than for component III. Under conditions where type A substance precipitated 90% of the lectin, types A2 and B precipitated151,199 66 and 13%, respectively, of component II, and 21 and 0% of component III. Neither of the lima-bean lectins precipitated with type O blood-group substance. 

Meyer et ah (M37) isolated two different types of carbohydrate material from hog gastric mucin. One of them had equimolecular amounts of glucosamine, hexuronic acid, acetyl groups, and sulfate, which was therefore thought to be mucoitin sulfuric acid. The second was a neutral polysaccharide, which will be discussed below. Wolfrom and Rice identified (W23) the hexuronic acid in this preparation as D-glucuronic acid. 

Nagata S, Ajioka Y, Nishikura K, et al. Co-expression of gastric and biliary phenotype in pyloric-gland type adenoma of the gallbladder immunohistochemical analysis of mucin profile and CDIO. Onco/Rep. 2007 17 721-729. 

Figure 1.9 Mucin-type Sequences of Glycoproteins. These structures share the common feature of N-acetylgalactosamine a-linked to the hydroxyl groups of seryl or threonyl residues otherwise they are extremely variable. Structures (a) to (d) occur in rat colonic mucus (Slomiany, Murty and Slomiany, 1980) (e) and (f) are of widespread occurrence and (g) is known from human gastric mucin and forms the inner part of several larger saccharides from human and porcine sources. Structure (a) is also very commonly found.

Natural sulfate acid esters occur as salts in many seaweed polysaccharides (138). They are also found widely distributed in the polysaccharides (139) of animal tissues (Chapter XII), such as those in skin, cartilage, cornea, and gastric mucin. Heparin (p. 720) (140), the natural blood anticoagulant, is a highly sulfated polysaccharide of this type and contains both sulfate acid ester groups and a sulfamic acid function, RNHSO2OH. 

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