Mouse studies engineered models

In an important study, Kirton et al. [5] engineered a mouse-human chimeric antibody and demonstrated that this was able to reduce leukocyte migration in various in vitro and in vivo mouse models. In particular, leukocyte migration to the peritoneal cavity was reduced by 40% in the thioglycollate inflammation model using mice expressing human SSAO/VAP-1 protein. The Finnish company Biotie Therapies Corporation, is in clinical development with an antibody to VAP-1 [54],... 

There are many reviews on constitutes a mouse model for human diseases (5-7), as well as models for specific diseases (8-22). It is beyond the scope of this chapter to discuss the pros and cons of each of these potential models, especially since a recent scan of the public literature and databases revealed over 1200 genetically engineered and spontaneous mouse mutations that have skin diseases that potentially serve as models for specific human diseases. Information on these are and where to find them is discussed below. Further, this chapter will not describe the usefulness of the mouse to study wound healing, and the reader is referred to other reviews on such (23, 24). 

The use of genetically engineered animals has the potential to supplant some of the traditional long-term (2-year) rodent studies. Mouse models have been developed for use as mechanistic models in cancer research. Potential alternatives to the 2-year rodent oncogenicity bioassay include the p53 knockout mouse and the Tg.AC mouse. ... 

Although not strictly a genetically engineered mouse model, mice have been developed in which mouse hepatocytes have been replaced by human hepa-tocytes. These mice have been used for metabolism and toxicity testing,65-69 although perhaps their most valuable application is for focused mechanistic in vivo studies. 

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