Mouse Population-Based Toxicology for Personalized Medicine and Improved Safety Prediction

MOUSE POPULATION-BASED TOXICOLOGY FOR PERSONALIZED MEDICINE AND IMPROVED SAFETY PREDICTION 

Department of Environmental and Occupational Health, Regulatory Sciences Program, The University of Arkansas for Medical Sciences, Little Rock, AR, USA 

It is now well accepted that genetic variants affect responses to drugs and chemicals (Kalow, 1965 Bums, 1968). One of the earliest studies in this field compared plasma dmg half-lives in identical and fraternal twin pairs and demonstrated that greater differences existed between the fraternal twins (Vesell and Page, 1968). In recent years, several more monogenic pharmacogenetic traits have been reported (Nebert et al., 2008). One example 

Drug Discovery Toxicology From Target Assessment to Translational Biomarkers, First Edition. Edited by Yvonne Will, J. Eric McDuffie, Andrew J. Olaharski, and Brandon D. Jetty. 

A promising new alternative is a translational pharma-cogenetic approach in which genetically diverse mouse populations serve as a surrogate for human populations. The major advantage of this approach is the potential for 

---