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Mouse behavior models depression

Schramm NL, McDonald MP, Limbird LE (2001) The alpha(2a)-adrenergic receptor plays a protective role in mouse behavioral models of depression and anxiety. J Neurosci 21 4875-4882... [Pg.161]

Schmidt P, Holsboer F, Spengler D (2001) Beta(2)-adrenergic receptors potentiate glucocorticoid receptor transactivation via G protein beta gamma-subimits and the phospho-inositide 3-kinase pathway. Mol Endocrinol 15 553-564 Schramm NL, McDonald MP, Limbird LE (2001) The alpha(2a)-adrenergic receptor plays a protective role in mouse behavioral models of depression and anxiety. J Neurosci 21 4875-4882... [Pg.223]

As examples for the wide field of specific disease areas and mouse models, we have included type 1 and 2 diabetes (Serreze and Baribault), cardiovascular disease (Howies), arthritis (Tak), skin disorders (Sundberg), cancer (Talmadge, Surguladze, and Li), the use of behavioral models for depression and anxiety (Kalueff), neurodegenerative diseases (Janus), neuromuscular diseases (Burgess), and infectious diseases (Medina). [Pg.427]

Several natural products have been evaluated in rodent models of nicotine withdrawal. An extract of Hypericum perforatum (St. John s Wort, a putative antidepressant, and inhibitor of serotonin reuptake) reversed somatically expressed withdrawal behaviors and locomotor depression in spontaneous withdrawal (Catania et al. 2003). A benzoflavone compound isolated from Passiflora incarnata, interfered with the induction of physical dependence. Coadministration with chronic nicotine prevented various subsequent indicators of withdrawal syndrome in the mouse, including jumping, locomotor inactivity, immobility in the swim test and naloxone-precipitated escape jumping (Dhawan et al. 2002). [Pg.425]

Whishaw IQ, Metz GA, Kolb B, Pellis SM (2001) Accelerated nervons system development contributes to behavioral efficiency in the laboratory mouse a behavioral review and theoretical proposal. Dev Psychobiol 39 151-170 Willner P (1984) The validity of animal models of depression. Psychopharmacology (fieri)... [Pg.34]

Cryan, J. F. and Mombereau, C. (2004) In search of a depressed mouse utility of models for studying depression-related behavior in genetically modified mice. Mol Psychiatry 9, 326-357. [Pg.280]

El Yacoubi M, Bouali S, Popa D, et al. Behavioral, neurochemical, and electro-physiological characterization of a genetic mouse model of depression. Proc Natl Acad Sci USA 2003 100(10) 6227-6232. [Pg.563]

The forced swim test [2,3], a model of learned helplessness or of behavioral despair, is conducted by forcing a rat or mouse to swim in an inescapable container filled with water. When placed in a swim tank, animals display escape-directed behaviors such as swimming, climbing, and diving. After an initial period of activity, animals become immobile or simply float in the water, using small movements to keep the head or nose above the water surface. The immobility (failure in the persistence of escape-directed behaviors) is frequently interpreted as despair-like behavior in which the subject has failed at escape attempts and adopts hopeless or depressed postures. [Pg.356]

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