Model behavior

One of the simplest cases of phase behavior modeling is that of soHd—fluid equilibria for crystalline soHds, in which the solubility of the fluid in the sohd phase is negligible. Thermodynamic models are based on the principle that the fugacities (escaping tendencies) of component are equal for all phases at equilibrium under constant temperature and pressure (51). The soHd-phase fugacity,, can be represented by the following expression at temperature T ... [Pg.224]

While the obvious value of in vivo animal models is clear, there also are instances—especially in cases of inflammatory arthritis, behavior, and tumor growth—where they have failed to be predictive of useful clinical activity in humans [51], For example, leukotriene (LTB4) antagonists showed activity in animal models of inflammatory arthritis yet failed to be useful in rheumatoid arthritis [52]. Similarly, dopamine D4 antagonists showed activity in animal behavior models previously predictive of dopamine D2 antagonists in schizophrenia. However, testing of dopamine D4 antagonists showed no efficacy in humans [53]. [Pg.190]

Glennon, R.A. and Lucki, I. Behavioral models of serotonin receptor activation. In Sanders-Bush, E., ed. The Serotonin Receptors. Clifton, NJ The Humana Press, 1988. pp. 253-293. [Pg.299]

Marlatt GA (1996). Taxonomy of high-risk situations for alcohol relapse Evolution and development of a cognitive-behavioral model. Addiction, 91, S37-49. [Pg.273]

Maldonado, R. and Rodriguez de Fonseca, F. Cannabinoid addiction behavioral models and neural correlates. /. Neurosci. 22 3326-3331, 2002. [Pg.926]

White, F. J., Holohean, A. M., and Appel, J. B. (1981) Lack of specificity of an animal behavior model for hallucinogenic drug action. Pharmacol. Biochem. Behav., 14 339-343. [Pg.44]

Dialkyl substitution on the alpha-carbon also abolishes activity, the a,a-dimethyl analog of DOM, Structure 10, is inactive in a variety of assays (10). Linking the two alpha-methyls to give the cyclopropyl analog Structure 11 restores activity in a cat behavioral model (10). The difference in activity between 10 and 11 has been ascribed to the inability of 10 to adopt an antiperiplanar... [Pg.61]

Jacobs, B. L. (1976) An animal behavior model for studying central serotonergic synapses. Life Sci., 19 777-786. [Pg.107]

Jacobs, B. L., and Trulson, M. E. (1981) An animal behavior model for decreased central serotonergic function. In Serotonin Current Aspects of Neurochemistry and Function, edited by B. Haber, S. Gabay, M. R. Issidorides, and S. G. A. Alivisatos, pp. 657-680. Plenum, New York. [Pg.198]