Morphine liposomal

Morphine (Avinza XR, Duramoiph, Infumorfh, MS Contin, Kadian SR, Oramorph SR, Palladone, Roxanol) Morphine, Liposomal (DepoDur)... 

Morphine Liposomal (DepoDur) [Analgesic/Opioid Agonist]... 

Figure 5.7 shows lipophilicity profiles (log D vs. pH) for an acid (warfarin), a base (tetracaine), and an ampholyte (morphine). The dashed curves correspond to the values determined in octanol-water and the solid curves, to values in liposome-water. As is readily apparent, the major differences between octanol and liposomes... 

Pethidine Hydrochloride Pethidine hydrochloride solutions are not compatible with barbiturates, aminophylline, morphine sulfate, sulfadiazine sodium, methicilline sodium, nitrofurantoin, phenytoin sodium, heparin sodium, sodium iodide, diethanolamine, sulfafurazol, acyclovir sodium, liposomal doxorubicin hydrochloride, frusemide, imipenem, and idarubicin. Visual incompatibilities are reported with mixtures of pethidine hydrochloride and cefoperazone sodium or mezlocillin sodium, nafcillin sodium and minocycline hydrochloride or tetracycline hydrochloride in 5% glucose injection.82 83... 

Generic Name morphine extended-release liposome injection... 

DepoDur is a sterile, non-pyrogenic, white to olf-white, preservative-free suspension of multi-vesicular lipid-based particles containing morphine sulfate, USP. The lipid carrier is a proprietary drug delivery system known as DepoFoam . After the administration of DepoDur into the epidural space, morphine sulfate is released from the multivesicular liposomes over a period of time [1-3] (Figures 44.2 and 44.3). 

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