Morantel tartrate

Morantel tartrate 556.425 N-methyl-1,3- Cattle, goat Liver (target) — 700... 

In the period 1992-1994, the drugs and groups of drugs screened by the National Residue Program included antibiotics, sulfonamides, ivermectin, halofuginone, levamisole, and morantel tartrate. The microbial assays applied by FSIS for monitoring antibiotics could detect chiortetracyciine, oxytetracycline, tetracy-... 

Table 13.6 National Residue Monitoring Program Results for Levamisole and Morantel Tartrate over the Period 1993-1994 in the United States...

Although the mode of action of morantel is believed to be similar to that of pyrantel, it has been shown that this drug may also interfere with the glucose metabolism of the worms. This is because of the fact that the fumarate-reductase system of Haemonchus contortus has been found to be sensitive to morantel tartrate at a high concentration of 2.5 x 10 M [41]. 

AI3-29747 Banminth II CP 12009-18 EINECS 247-481-6 Morantel tartrate Parateot Pyrimidine, 1,4,5,6-tetrahydro-1-methyl-2-(2-(3-methyl-2-thienyl)ethenyl)-, (E)-, (R-(R, R ))-2,3-... 

Morantel The conventional use of veterinary anthelmintics is for the therapy of existing Infections and does not prevent rapid reinfection in circumstances of continuous environmental challenge such as pasture grazing. A new sustained release morantel tartrate delivery system for cattle has been described.42 a single oral treatment administered at turnout provides protection against gastrointestinal nematode infection for the entire grazing season. Improved performance compared with untreated or conventionally medicated cattle was also observed. 

New anthelmintic agents which are already in use in veterinary medicine have been found in two cyclic amidine derivatives, pyrantel tartrate (Banminth, Strongid) (269) and morantel tartrate (Banminth II) (270). For references concerning their evaluation in sheep, cattle, pigs, horses, dogs, and man see Ref. 260. These compounds are most probably prepared by condensation of the appropriate thiophen aldehyde with 1,4,5,6-tetra-hydro-l,2-dimethylpyrimidine. Extensive investigations on structure-... 

Lanusse, C.E. Gascon, L.H. Ranjan, S. Prichard, R.K. Morantel tartrate release from a long-acting intraruminal device in cattle pharmacokinetics and gastrointestinal distribution, J.Vet.Pharmacol.Ther., 1992,15, 117-123. 

The role played by fumarate reductase inhibition in the mode of action of anthelmintics was further studied. Enz3mie isolated from thiabendazole-sensitive Haemonchus was inhibited by thiabendazole, cambendazole, levamisole, morantel tartrate and disophenol, but not by mebendazole. Enzyme from a thiabendazole-resistant strain was similarly affected, except that the inhibitory effect of cambendazole was reduced and that of thiabendazole was not demonstrable. In lambs, after 4 generations of Haemonchus strain BPL-2 had been exposed successively to single doses of cambendazole at 5, 5, 10 and 20 mg/kg, this parasite was less susceptible to cambenda-... 

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