Suture monofilament

Monofilament fiber extrusion, 79 790 VDC copolymers in, 25 725, 727-728 Monofilament sutures, 24 218 Monofilament suture threads, 24 207 Monofunctional glycidyl ethers, 70 376-377 Monoglycerides, 72 55 melting points of, 70 821 Monohaloalkylations, 72 167 Monohalogenoboranes, 73 636... 

The aliphatic poly(ether lactonejs are a group of synthetic polymers with high elasticity and high tissue absorptivity [293]. The ether function in the polymer backbone adds flexibility to the ester chain. Ring-opening polymerization of l,4-dioxan-2-one yields an elastic polymer, polydioxanone, with a tensile strength similar to that of human tissue [294]. Polydioxanone has been successfully used to prepare monofilament sutures, with a flexibility superior to that of PGA sutures [294]. Recently, the lipase-catalyzed polymerization of polydioxanone was demonstrated [295]. 

PDS is produced by polymerization of p-dioxanone. The polymer has unusually high flexibility and, unlike copolymers of lactic and glycolic acid, can be used to produce a variety of monofilament sutures. Since PDS is a polyester, like pLA and pGA, the polymer chains break down by hydrolysis. Currently, PDS is also used in orthopedic applications (Orthosorb ), as a fixation element for bone repair. 

Possess a prolonged strength profile, especially during the initial postoperative period, as braided multifilament or monofilament sutures... 

However, until recently, the use of a combination of controlled branching (polyaxial chain geometry) and chain segmentation or block formation of the individual branches to produce absorbable polymers with tailored properties has been overlooked. Accordingly, for addressing this area, the synthesis and available properties of this new family of copolyesters and monofilament sutures therefrom are discussed in this chapter. 

Typical Examples of Polyaxial Copolyesters and Properties of Monofilament Sutures Therefrom... 

Using the general method for preparing polyaxial copolyesters, several compositions were prepared and converted to monofilament sutures. The sutures were then evaluate for clinically relevant properties such as those discussed earlier by Shalaby These include ... 

The composition and thermal data of typical polymers and tensile properties of their respective nonsterile monofilaments are summarized in Tables 3.3 and 3.4, respectively. The monofilaments were then radiochemically sterilized using 5 and 7.5 kGy gamma radiation and a polyformaldehyde package insert as described earlier by Correa et al. ° The tensile properties of typical sterile monofilament sutures and their BSR profiles were determined after incubation in a phosphate buffer at 37°C and pH 7.4 to simulate their in vivo profile. The tensile properties and BSR data of a typical radiochemically sterilized monofilament suture are summarized in Table 3.5. 

Typical In Vitro BSR Data of a Radiochemically Sterilized Monofilament Suture ... 

Having demonstrated that the radiation dose during RC-S can be used to modulate the BSR of monofilament sutures based on polyaxial copolyesters (Section 3.2.4), Anneaux and co-workers studied the effect of composition... 

Copolyester Compositions and BSR Data of Their Respective Monofilament Sutures... 

The BSR data of fhe high glycolide segmented monofilament sutures are summarized in Table 3.6 and indicate that ... 

The monofilament suture M6, having a slightly higher glycolide content than suture M7, was less sensitive to radiolytic degradation. 

Segmented copolymers geared for the production of compliant monofilament sutures described in Chapter 3 dealt with the use of end-grafting of an amorphous, or low melting, polyaxial polymeric initiator with cyclic monomers to form crystalline end-grafts. In this particular chain design, the... 

One-Step Synthesis of Caprolactone-Glycolide Segmented Copolymers and Monofilament Sutures Thereof... 

Two of the early polymers described in Table 8.1 were melt spun into monofilament sutures, which exhibit the tensile properties shown in Table 8.3. 

A new series of high molecular copolymers was prepared typical properties of these polymers are outlined in Table 8.4. Monofilaments product from these polymers were evaluated for their physical and in vivo properties as monofilament sutures. Typical results of such evaluation are summarized in Table 8.4. 

Polymer Number Monofilament Suture Physical Properties Suture In Vivo BSR at One Week ... 

Tensile and in vitro and breaking strength retention data of typical monofilament sutures made of the polymers described in Section 8.3.2 are summarized in Table 8.6. The data in Table 8.6 indicate that the polymers described in Table 8.5 can be converted to monofilament sutures with competitive strength retention and breaking strength profiles as the commercially available braided sutures made of polyglycolide or 90/10 poly(glycolide-co-/-lactide). 

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