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Breaking strength retention

Figure 1. In vivo breaking strength retention of Poly(i lactide) and 95/5 Poly(l lactide-cc>-glycolide). Figure 1. In vivo breaking strength retention of Poly(i lactide) and 95/5 Poly(l lactide-cc>-glycolide).
In-Vivo Absorption and breaking strength retention studies. For comparing PDS monofilament in-vivo properties with copolymeric fibers, a second 90/10 PDO/glycolide copolymer (II-A) was prepared and processed following similar schemes to those used for copolymer II. [Pg.168]

Ethylene oxide sterilized laonofilaments of copolymer II-A and a poly(p-dioxanone) were compared in terms of their in-vivo absorption and BSR (breaking strength retention) profiles. The BSR and absorption studies were conducted in rats according to the procedures described elsewhere. The comparative data of these studies are given in Table V. [Pg.170]

S entails the use of about 5 to 7.5 kGy of gamma radiation and a polyformaldehyde package insert capable of a radiolytic, controlled release of formaldehyde in a hermetically sealed package imder dry nitrogen. The process has been applied successfully to absorbable sutures without compromising their clinically relevant properhes, such as their in vivo breaking strength retention. Typical BSR data of radiochemically sterilized suture braids and controls are reported by Anneaux and co-workers. ... [Pg.10]

Anneaux, B. L., Atkins, G. G., Linden, D. E., Corbett, J. T., Fulton, L. K. and Shalaby, S. W, In vivo breaking strength retention of radiochemically sterilized absorbable braided sutures, Trans. Soc. Biomater., 24, 157, 2001. [Pg.12]

In vitro breaking strength retention and mass loss during incubation in a phosphate buffer at 37°C and pH 7.4... [Pg.29]

In vivo breaking strength retention using a rat model where the sutures are implanted subcutaneously for 1 to 4 weeks and individual lengths are explanted periodically to determine percent of retained breaking strength... [Pg.29]

Prior to in vivo evaluation of the suture breaking strength retention, some of the sutures were subjected to radiochemical sterilization using a 5-kGy dose.i° This sterilization process has been described briefly in Chapter 1 and can be used to achieve suture sterility without compromising its breaking strength. This is contrary to what is known to occur when absorbable sutures are radiation-sterilized using the traditional dose of about 25 kCy. [Pg.29]

In a study by Carpenter and co-workers, three polymers (I, III, and IV) were made using TMP to prepare the respective polymeric initiators, as described in Section 3.23P In an effort to produce compliant monofilaments, these polymers were extruded to monofilaments and processed under slightly different conditions from those used in preparing their counterparts in section 3.2.3. One of the polymers (I) was used to prepare a second set of monofilaments for studying the effect of radiation dose, under a typical radiochemical sterilization process (RC-S) on their in vitro breaking strength retention (BSR). [Pg.31]

Effect of Composition on the Breaking Strength Retention (BSR) of Radiochemically Sterilized Sutures... [Pg.32]

Tensile and in vitro and breaking strength retention data of typical monofilament sutures made of the polymers described in Section 8.3.2 are summarized in Table 8.6. The data in Table 8.6 indicate that the polymers described in Table 8.5 can be converted to monofilament sutures with competitive strength retention and breaking strength profiles as the commercially available braided sutures made of polyglycolide or 90/10 poly(glycolide-co-/-lactide). [Pg.109]

In vitro breaking strength retention in phosphate buffer solution at pH 7.4 and 37°C. [Pg.110]

Table 6.4 In vivo breaking strength retention of sterilized, dyed, RCS, safil PG braided sutures... Table 6.4 In vivo breaking strength retention of sterilized, dyed, RCS, safil PG braided sutures...
The in vivo breaking strength retention (BSR) of sutures is commonly evaluated by implanting the suture in laboratoiy animals, usually subcutaneously. The suture strands are recovered after various periods of in vivo residence and their breaking strength is determined using an appropriate tensiometer. [Pg.48]

Special grade poly(p-dioxanone) synthetic absorbable polymer has been developed into monofilament PDS suture, formulated to provide wound support through an extended healing period, as well as to minimize the variability of breaking strength retention and absorption and to invoke minimal tissue reaction. These features are particularly heneficial in critical applications, such as those involving slowly healing tissues. [Pg.51]

Extrusion of the poly (p-dioxanone-co-L(-) lactide) segmented and random copolymers was performed in a similar fashion as that of poly (p-dioxanone). The tensile properties were determined with an INSTRON tensile tester. The breaking strength retention (BSR) in vivo of the fibers was determined by implanting two strands of the fiber in the dorsal subcutis of each of a number of Long-Evans rats. [Pg.53]


See other pages where Breaking strength retention is mentioned: [Pg.162]    [Pg.162]    [Pg.15]    [Pg.16]    [Pg.19]    [Pg.21]    [Pg.23]    [Pg.23]    [Pg.25]    [Pg.37]    [Pg.42]    [Pg.49]    [Pg.292]    [Pg.294]    [Pg.388]    [Pg.389]    [Pg.682]    [Pg.696]    [Pg.48]    [Pg.48]    [Pg.54]    [Pg.56]    [Pg.30]    [Pg.157]    [Pg.164]    [Pg.292]    [Pg.294]   
See also in sourсe #XX -- [ Pg.15 , Pg.16 ]

See also in sourсe #XX -- [ Pg.164 ]




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