Molecular recognition/biomolecular

Optical or piezo-resistive read-out detectors can be employed for design of microcantilevers-based nanomechanical biosenors for direct detection of biomolecular interactions.73 Microcantilevers translate molecular recognition of biomolecules into nanomechanical motion, and high-throughput platforms using arrays of cantilavers can be used for simultaneous measurement and read-out of hundreds of samples. 

Cooper, M.A. and Singleton, V.T. (2007) A survey of the 2001 to 2005 quartz crystal microbalance biosensor literature applications of acoustic physics to the analysis of biomolecular interactions. Journal of Molecular Recognition, 20, 154-184. 

Brooijmans, N. and Kuntz, I.D. (2003) Molecular recognition and docking algorithms. Annual Remeiv of Biophysics and Biomolecular Structure, 32, 335—373. 

The concept of molecular recognition has a profound impact upon our understanding of a wide range of fundamental events, e.g., biomolecular activity, crystallization processes, and physicochemical signaling mechanisms. The relevance of strong hydrogen bonds to such phenomena remains unchallenged, and it is likely that further studies of the nature of such interactions will have important ramifications for supramolecular chemistry as a whole. 

Substantial progress in the application of QDs for optical sensing and biosensing was accomplished in the past decade, and several reviews have summarized the advances in this field [56-58]. In this chapter, the aim is to emphasize the use of QDs for following molecular and biomolecular recognition events, and to probe the dynamics of chemical or biomolecular transformations by the application of modified hybrid QDs. 

The next stage in the intracomplex ET study linked by noncovalent weak interactions should be the construction of a biomolecular assembly to understand highly ordered biological systems. This section focuses on artificially created ET models formed by molecular-recognition events on protein surfaces. The topics of native protein-protein... 

Jelesarov, I., Bosshard, H.R. (1999) Isothermal titration calorimetry and differential scanning calorimetry as complementary tools to investigate the energetics of biomolecular recognition. Journal of Molecular Recognition, 12 (1), 3-18. 

Conji ated polymers designed for the detection of molecules or biomolecules are subject to a growing interest [164,165,226]. PT derivatives have also been developed for molecular and biomolecular recognition. Selected examples are described in this section. 

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