Biomolecular assemblies

Various information networks such as gene, intercellular, intracellular, sensory, and brain information networks are implemented in biological systems. The information transduction, conduction, and retreaval functions are integrated in these bioinformation networks. Every bioinformation network is totally consisted of organic molecules including protein. A keen interest has been focused on the molecular mechanisms of the information transduction by the biomolecular assemblies because of their excellent selectivity and sensitivity. This chapter concerns protein molecular... 

Lundqvist, A., Lundahl, P. Chromatography on cells and biomolecular assemblies. / Chromatogr B Biomed Sci Appl 1997, 699, 209-220. 

Wu, Y. (2004). Biomolecular assembly and design of high-throughput bioanalydcal systems. In Biomolecular Assembly and Design of High-Throughput Bioana-lytical Systems Ph.D. Thesis Chemical Engineering. University of New Mexico, Albuquerque. 

An attractive route to creating stable multilayers is electrostatic self-assembly using polyelectrolytes. Since the interaction between the polymer layer and the substrate, or between alternating layers, is based on electrostatic interactions, the chemical nature of the electrostatic components can be varied systematically. As a result, there is an extensive literature based on, among others, polymer-polymer, polymer-organic, polymer-inorganic, and polymer-biomolecular assemblies. 

Ashbaugh, H. S. and Pratt, L. R Scaled particle theory and the length-scales involved in hydrophobic hydration of aqueous biomolecular assemblies. Technical Report LA-UR-03-2144, Los Alamos National Laboratory (2004). 

Leikin S, Parsegian VA. Temperature-induced complementarity as a mechanism of biomolecular assembly. Ihoteins Struct. Func. Genet. 1994 19 73-76. 

Yang Y, Wang H, Eirie DA. Quantitative characterization of biomolecular assemblies and interactions using atomic force microscopy. Methods 2354 29 175-187. 

There has been considerable interest in recent years in the formation of condensed films of purine and pyrimidine bases at the solid-liquid interface. It is well recognised that non-covalent affinities between base pairs play a prevalent role in determining nucleic acid conformation and functionality. Likewise, there has been interest in the role of substrate and non-covalent intermolecular interactions in the configuration of ordered monolayers of purine and pyrimidine bases. There is also more general interest in the interaction of bases with metal surfaces and metal complexes. In the latter case it is noted that the biological role of nucleic acids and certain nucleotides are dependent on metal ions, particularly Mg, Ca, Zn, Mn, Cu and Ni. " Also certain metal complexes, notably of platinum, have the anti-tumour activity, which is linked to their ability to bind to bases on DNA. On a different note, the possibility that purine-pyrimidine arrays assembled on naturally occurring mineral surfaces might act as possible templates for biomolecular assembly has been discussed by Sowerby et al. 

Ackrill T, Anderson DW, Macmillan D (2010) Towards biomolecular assembly employing extended native chemical ligation in combination with thioester synthesis using an N— S acyl shift. Biopolymers 94 495-503... 

Jungbauer A, Hahn R. Polymethacrylate monohths for preparative and industrial separation of biomolecular assemblies. /. Chromatogr. A 2008 1184 62-79. 

The next stage in the intracomplex ET study linked by noncovalent weak interactions should be the construction of a biomolecular assembly to understand highly ordered biological systems. This section focuses on artificially created ET models formed by molecular-recognition events on protein surfaces. The topics of native protein-protein... 

On a molecular scale, the accurate and controlled application of inter-molecular forces can lead to new and previously unachievable nanostructures. This is why molecular self-assembly (MSA) is a highly topical and promising field of research in nanotechnology today. With many complex examples all around in nature, MSA is a widely perceived phenomenon that has yet to be completely understood. Biomolecular assemblies are sophisticated and often hard to isolate, making systematic and progressive analyzes of their fundamental science very difficult. What in fact are needed are simpler MSAs, the constituent molecules of which can be readily synthesized by chemists. These molecules would self-assemble into simpler constmcts that can be easily assessed with current experimental techniques [37, 38]. 

Shih, W. (2008), Biomolecular assembly - dynamic DNA, Nature Materials, 7, 98-100. 

Biomolecular assembly The spontaneous packing of biological molecules into larger-scale structures resulting from the action of intermolecular forces. 

Perkins, S.J., in Dynamic Properties of Biomolecular Assemblies, Harding, S.E., Rowe, A.J. (eds.), Cambridge Royal Society of Chemistry, 1989, p.226. 

---