Traumatic brain injury moderate hypothermia

Aibiki M, Maekawa S, Yokono S. 2000. Moderate hypothermia improves imbalances ofthromboxane A2 and prostaglandin 12 production after traumatic brain injury in humans. Crit... 

Clifton G. L., Jiang J. Y., Lyeth B. G., Jenkins L. W., Hamm R. J., and Hayes R. L. (1991) Marked protection by moderate hypothermia after experimental traumatic brain injury../. Cereb. Blood Flow Metab. 11, 114—121. 

Chatzipanteli K., Wada K., Busto R., and Dietrich W. D. (1999) Effects of moderate hypothermia on constitutive and inducible nitric oxide synthase activities after traumatic brain injury in the rat. J. Neurochem. 72, 2047-2052. 

Kline A. E., Bolinger B. D., Kochanek P. M., et al. (2002) Acute systemic administration of interleukin-10 suppresses the beneficial effects of moderate hypothermia following traumatic brain injury in rats. Brain Res. 937, 22-31. 

Management of Traumatic Brain Injury With Moderate Hypothermia... 

Early reports of therapeutic hypothermia for severe traumatic brain injury can be traced back to the first half of the 20th century. It is only within the last two decades that clinical studies have demonstrated that therapeutic moderate hypothermia for brief durations can improve patient outcomes following brain injury. The historical background, recent clinical experience, and mechanisms of action of moderate hypothermia are reviewed. 

Therapeutic Moderate Hypothermia in Experimental Traumatic Brain Injury Models... 

Marion D. W. (1997) Therapeutic moderate hypothermia for severe traumatic brain injury. J. Intern. Care Med. 12, 239-248. 

It is known from animal models with global ischemia and traumatic brain injury that moderate hypothermia attenuates secondary brain damage by reducing cerebral ischemia and postischemic brain edema and preserving the blood-brainbarrier. Even though hypothermia has potent cerebroprotective effects after experimental focal ischemia, clinical studies on hypothermic therapy after MCA infarction were not available until recently. We performed a pilot study investigating the efficacy, feasibility, and safety of induced moderate hypothermia in the therapy of patients with acute, severe MCA infarction and increased ICP. 

Marion D. W., Penrod L. E., Kelsey S. F., etal. (1997) Treatment of traumatic brain injury with moderate hypothermia. N. Engl. J. Med. 336,540-546. 

Resurgence of Hypothermia as a Treatment for Brain Injury. The Effects of Hypothermia and Hyperthermia in Global Cerebral Ischemia. Mild Hypothermia in Experimental Focal Cerebral Ischemia. Hypothermic Protection in Traumatic Brain Injury. Postischemic Hypothermia Provides Long-Term Neuroprotection in Rodents. Combination Therapy With Hypothermia and Pharmaceuticals for the T reatment of Acute Cerebral Ischemia. Intraoperative and Intensive Care Management of the Patient Undergoing Mild Hypothermia. Management of Traumatic Brain Injury With Moderate Hypothermia. Hypothermia Clinical Experience in Stroke Patients. Hypothermia Therapy Future Directions in Research and Clinical Practice. Index. 

---