Mitogenicity inhibitory activity

Crisi, G. M., Katz, I. R., Zucker, M. B., and Thorbecke, G. T. (1996). Induction of inhibitory activity for B cell differentiation in human CDS T cells with pokeweed mitogen, dimaprit, and cAMP upregulating agents countersuppressive effect of platelet factor 4. Cell. Immunol. 172, 205-216. 

IkB inhibitory protein kappa B lCAM-1 intercellular adhesion molecule 1 lL-1 interleukin-1 LDL low density lipoprotein MAPKs mitogen activated protein kinases MCP-1 macrophage chemotactic protein 1 M-CSF macrophage colony stimulating factor mmLDL minimally modified LDL NAC A-acetylcysteine NF-kB nuclear factor-kappa B oxLDL oxidised LDL PKC protein kinase C PMA phobol myristate acetate ROS reactive oxygen species TNF-a tumour necrosis factor alpha AM-1 vascular cell adhesion molecule 1... 

CBi and CB2 seem to couple to inhibitory Gj and/or G0 proteins. CBi receptors are known to effect adenylate cyclase, a variety of potassium and calcium currents, and the mitogen-activated protein kinase pathway. CBi receptors have been shown to activate at least six subtypes of Gj and G0 proteins, supporting reports that they effect a wide variety of intracellular signaling systems. In contrast to CB receptors, CB2 receptors do not seem to effect ion currents directly (Breivogel et al., 2001). 

Fig. 8.1 A schematic diagram illustrating the involvement of NF-k I in gpl20, ROS, NO, PG, IL-1/3 and TNF-a-mediated neurotoxicity. NMDA-R, N-Methyl-D-aspartate receptor, cPLA2, cytosolic phospholipase A2 lyso-PtdCho, lysophosphatidylcholine AA, arachidonic acid cAMP, cyclic adenosine monophosphate PKA, protein kinase A TNF-a, tumor necrosis factor-a TNF-a-R, TNF-a-receptor IL-1/8, interleukin-1 /3 IL-l/i-R, IL-1/8-receptor, IL-6, interleukin-6 MARK, mitogen-activated protein kinase NO, nitric oxide PG, prostaglandins EP-R, prostaglandin receptors NF-kB, nuclear factor-icB NF-kB-RE, nuclear factor-/cB-response element I/cB, inhibitory subunit of NF-icB HIV-1, human immunodeficiency virus type 1 gpl20, HIV-1 coat glycoprotein COX-2, cyclooxygenase-2 iNOS, inducible nitric oxide synthase SPLA2, secretory phospholipase A2 SOD, superoxide dismutase MMP, matrix metalloproteinase and VCAM-1, vascular adhesion molecule-1...

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