Miscellaneous analogues

Miscellaneous Analogues of PGI.- The Corey lactone (2g) was converted into the y-lactam (284) (Scheme 39) and by well-established reactions into the lactam (285), the thiolactam (266)... 

INHIBITORS OF MAMMALIAN COLLAGENASES Non-substrate analogue inhibitors Substrate analogue inhibitors Phosphorus-based inhibitors Sulphur-based inhibitors Hydroxamate inhibitors tt-Carboxyalkyl inhibitors Miscellaneous inhibitors... 

Table 3.25. NORADRENALINE-DEPLETING ACTIVITY OF GUANETHIDINE ANALOGUES AND MISCELLANEOUS GUANIDINES...

The management of cancer includes treatment with alkylating agents (nitrogen mustards and alkyl sulfonates), antimetabolites (methotrexate and purine analogues), natural products (vinca alkaloids and taxol), miscellaneous compounds (hydroxyurea, procarbazine, and m-platinum), hormones (estrogens and corticosteroids), and radioactive isotopes. 

Miscellaneous Physical Chemistry. A kinetic study has been made of the electrochemical reduction of /8-carotene. The photoelectron quantum yield spectrum and photoelectron microscopy of /3-carotene have been described. Second-order rate constants for electron-transfer reactions of radical cations and anions of six carotenoids have been determined. Electronic energy transfer from O2 to carotenoids, e.g. canthaxanthin [/8,/3-carotene-4,4 -dione (192)], has been demonstrated. Several aspects of the physical chemistry of retinal and related compounds have been reported, including studies of electrochemical reduction, the properties of symmetric and asymmetric retinal bilayers, retinal as a source of 02, and the fluorescence lifetimes of retinal. Calculations have been made of photoisomerization quantum yields for 11-cis-retinal and analogues and of the conversion of even-7r-orbital into odd-TT-orbital systems related to retinylidene Schiff bases. ... 

MEDICINAL AZIDES Antiproliferative azides Azido-substituted antifolates Azidotriazenes Myo-mositol analogues Azidonucleoside antitumour agents Azido-substituted anti-infective agents Zidovudine and related nucleosides A zido-substituted antibiotics Miscellaneous anti-infective azide derivatives Anti-inflammatory azides Zidometacin... 

Miscellaneous Heterocyclic Steroids.—I3-Aza-15-thia-I8-norequilenin, 11-oxo-15,l6-diaza-equilenin, and 18-nor-equilenin analogues as well as ring-A-furan, oxazine, and oxazole analogues of equilenin have been synthesised. The preparation of the thiadiaza-steroids (481) has also been briefly reported. 

Miscellaneous Spectroscopy and Physical Chemistry. The photochemistry of retinal and analogues and visual pigments has been reviewed.Another review discusses flash photolysis and pulse radiolysis of some carotenoids and visual pigments.Theoretical and experimental studies of carotenoids by various spectroscopic methods have been reported. Similar studies on retinal and derivatives have also been published. ... 

Miscellaneous Reactions of Methylenephosphoranes.—The synthesis of three-membered rings by means of phosphorus ylides has been reviewed and there have been several new reports of this type of reaction. Optically active a,p-un-saturated esters have been converted into cyclopropanes highly stereoselectively by reaction with isopropylidenetriphenylphosphorane as the key step in syntheses of both (li ,3 )-chrysanthemic acid methyl ester (53) and the (IR) cis-gem dibromovinyl analogue (54). The addition of reactive phosphonium ylides to functionalized 1,3-butadienylphosphonates provides a new synthesis of 2-cyclopen ten-1 -ylphosphonates (5 5). ... 

Miscellaneous Applications.— The Wittig reaction of ( ) 6,10-dimethyl 5,9-undecadien-2-ylidenetriphenylphosphorane with ethyl rra/ (2-carboxaldehyde)-cyclopropanecarboxylate yields a 1 1 mixture of ( )- and (Z)-alkenes. The former isomer was converted into an analogue (161) of a proposed intermediate in squalene biosynthesis. (10 ,ll/ )-(+)-Squalene-10,ll-epoxide (164), identical to a constituent of the red algae Laurencia okamuri, was isolated from the isomeric mixture produced from a Wittig reaction of the ylide (162) with the aldehyde (163). ... 

Cytosine and its analogues Isocytosine and its derivatives Miscellaneous aminohydroxypyrimidines... 

The base cytosine (XLIX, 4-amino-2(lH)pyrimidone), which, paired with guanine, is present in both DNA and RNA, may be consider the most important parent structure in this class of compounds. Its isomer, isocytosine (L, 2-amino-4(3H)pyrimidone), while not found per se in the nucleic acids, exists as the pyrimidine moiety of guanine (LI), and of the vitamin folic acid (LII). Many analogues of (XLIX) and (L) have been prepared for biological study. Other analogues are found in nature. This section is divided into three parts, including compounds of type (XLIX), (L) and other miscellaneous aminohydroxypyrimidines. Uracils, barbiturates, and 5-hydroxypyrimi-dines which contain amino substituents are found in preceding sections. 

Antivirals for hepatitis viruses Nucleoside analogues Nucleotide analogues Miscellaneous... 

The following miscellaneous compounds have also been reported 2 a-D-Gal -(l 2)-0-D-Man -(1 4)-L-Rha (analogue of the repeat-... 

Carbocyclic Nucleoside Analogues Nucleoside Phosphates and Phosphonates Ether, Acetal, and Ester Derivatives Miscellaneous Nucleoside Analogues Reactions... 

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