Miscellaneous Nucleoside Analogues

3 -ketonucleoside intermediate reacts further with the Grignard 

Direct ring opening of the epoxide in 1 -(5 -0-trityl-2, 3 -anhydro- 

Convenient and high-yielding procedures have been described for the periodate oxidation-borohydride reduction of N-acyl-5 -0-monoethoxy-trityl ribonucleosides. 

166) on the similarly rapid acid hydroly-The hydrolysis of 9-S-D-ribofuranosy1-purine in alkali has been studied the reaction proceeds via initial 

2 -Deoxyguano8ine was selectively labelled with deuterium at C-4, via base-catalysed exchange of the 5 -aldehyde  

There has been an extended report on the synthesis of S -epi-bicyclonucleosides of type 242 (see Vol. 29, p. 297) and their incorporation into oligodeoxy-nucleotides.  

A novel type of nucleoside analogue reported for the first time is the thietane 261. This was prepared from L-ascorbic acid, which was converted into the thietane 260 (sugar carbons numbered) by a process involving inversion of 

Reagents i. MCPBA ii, thymine, TmsOTf, EtsN, Znl2, toluene iii, NaOMe, MeOH 

There have been reports on the synthesis of chiral cyclopropyl analogues of type and earlier work (Vol. 28, p. 298, and Vol. 29, p. 298-9) has been 

The extended thymidine analogues 264 and 265 (both anomers in both cases) have been prepared and incorporated into oligodeoxynucleosides by both 3 - 3 and 3 — 5 linkages to study conformational aspects of o/r-DNA sequences. The synthesis of 264 involved reduction of a glycosyl cyanide, followed by elaboration of the heterocycle, whilst 265 was made by Wittig reaction-Michael cyclization on a 2-deoxyribose derivative, again followed by reduction and heterocycle synthesis. Some compounds with heterocyclic groups attached at C-5 of a ribose unit are mentioned in Chapter 10. 

---

Carbocyclic Nucleoside Analogues Nucleoside Phosphates and Phosphonates Ether, Acetal, and Ester Derivatives Miscellaneous Nucleoside Analogues Reactions... 

Antivirals for hepatitis viruses Nucleoside analogues Nucleotide analogues Miscellaneous... 

MEDICINAL AZIDES Antiproliferative azides Azido-substituted antifolates Azidotriazenes Myo-mositol analogues Azidonucleoside antitumour agents Azido-substituted anti-infective agents Zidovudine and related nucleosides A zido-substituted antibiotics Miscellaneous anti-infective azide derivatives Anti-inflammatory azides Zidometacin... 

---