Mirabilis

For the electronic theory of organic chemistry 1926 was the annus mirabilis, and, particularly, as they applied to aromatic substitution, the... 

Susceptible Gram-negative organisms such as some Escherichia coli and Proteus mirabilis. 

None of Einstein s first four papers published between 1901 and 1904 foreshadowed his explosive creativity of 1905, his annus mirabilis, in which he produced in March, his proposal of the existence of light quanta and the photoelectric effect, work for which in 1922 he received the Nobel Prize in April, a paper on the determination of molecular dimensions, which earned him his Ph.D. m Zurich m May, his theory of special relativity in September, a sequel to the preceding paper containing the relation E = mc. Any one of these papers would have made him greatly renowned their totality made him immortal. 

More recently, miraziridine A (113) was isolated from a marine sponge related to Theonella mirabilis and shown to inhibit the cysteine protease cathepsin B. It has been shown that the aziridine ring plays a key role in this biological activity and gives rise to irreversible inhibition of cathepsins B and L, presumably through... 

Tributyltin(IV) derivatives of six different pharmaceutically active carboxylates were synthesized and their antibacterial activities were tested using 10 different bacteria (B. cereus, C. diphtheria, E. C. ETEC, K. pneumonia, P. mirabilis, P. aeroginosa,... 

The LPS from Proteus species contain amino acids linked as amides to acidic sugars. Thus, L-lysine is linked by way of N-6 to a D-galacturonic acid residue (52) in the LPS from P. hauseri, but by way of N-2 to a D-glucu-ronic acid residue in the LPS from P. mirabilis 027. The latter LPS also contains L-alanine, linked to the carboxyl group of a D-galacturonic acid residue. 

Bacteria which are almost always sensitive to the sulphonamides include Strep, pneumoniae, /3-haemolytic streptococci, Escherichia coli and Proteus mirabilis those almost always resistant include Enterococcus faecalis, Ps. aeruginosa, indole-positive Proteus and Klebsiella whereas bacteria showing a marked variation in response include Staph, aureus, gonococci, El. influenzae and hospital strains of E. coli and Pr. mirabilis. 

Resistance to quinolones by efflux has been described in Staph, aureus and Proteus mirabilis. This gene has been designated nor A in Staph, aureus and is homologous to membrane transport proteins coupled to the electromotive force. These proteins have the ability to remove small amounts of quinolone from cells normally and nor A may have arisen as a result of mutations under selective pressure from quinolone use, resulting in a transport protein with increased affinity for these agents. 

Acquired, non-plasmid-encoded resistance to biocides can result when bacteria are exposed to gradually increasing concentrations of a biocide. Examples are provided by highly QAC-resistant Serratia marcescens, and chlorhexidine-resistant Ps. mirabilis, Ps. aeruginosa md Ser. marcescens. 

Urease assay. When Proteus mirabilis grows in a urea-containing medium it hydrolyses the urea to ammonia and consequently raises the pH of the medium. This production of urease is inhibited by aminoglycoside antibiotics (inhibitors of protein synthesis Chapter 8). In practice, it is difficult to obtain reliable results by this method. 

Sasaki, N. et al.. Detection of UDP-glucose cyclo-DOPA 5-O-glucosyltransferase activity in four o clocks (Mirabilis jalapa L.), EEBS Lett, 568, 159, 2004. 

Piattelh, M., Minale, L., and Nicolaus, R.A., Pigments of Cenhospermae. V. Betaxanthins from Mirabilis jalapa L., Phytochemistry, 4, 817, 1965. 

Chlorate can serve as electron acceptor under anaerobic conditions (Thorell et al. 2003 Coates et al. 1999), and chlorate reductase has been found both in organisms such as Proteus mirabilis that can reduce chlorate but is unable to use to couple this to growth, and in true chlorate-respiring organisms. 

Moreover, it has been recognized that protonation of the Fe =0 group induces an increase of the quadrupole splitting with respect to the nonprotonated form. As a typical example, we mention the low-pH and high-pH forms of catalase from Proteus mirabilis [198] in Table 8.4. 

Glauber, Johann Rudolf. The complete works of Rudolph Glauber trans Chris. Packe. Sal mirabilis. [Richardson (TX)] R.A.M.S., 1983. [1], pp. 1073-1105... 

McGurk, J.J.N. Roger Bacon, Doctor Mirabilis. Hist Today 24 (1974) 489-498. 

Palter, Robert. The annus mirabilis of Sir Isaac Newton, 1666-1966. Cambridge (MA) MIT Press, 1970. viii, 351 p. 

Figure 14.1 MALDI MS of Enterobacter cloacae and Proteus mirabilis.

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