Minimum inhibitory

Table 3. Representative Minimum Inhibitory Concentrations for Urinary Tract Organisms by Sulfamethoxazole (SMX), Trimethoprim (TMP), and Their Combination...

Table 1. Minimum Inhibitory Concentration (MIC) of Chloramphenicol and Thiamphenicol Against Sensitive Organisms...

Table 5. Minimum Inhibitory Concentrations (MIC q ) of Florfenicol (2) and Other Antibiotics Against Bacterial Pathogens Isolated from Fish in Japan, Jg/mL...

Minimum Inhibitory Concentration measured by dilution of test compound in agar inoculated with microorganism. 

Minimum inhibitory concentration for 90% of the strains used. jJ-g/ruL All are nonfermentors except the Enterohacteriaceae. 

Although most /3- lactam antibiotics bind covalently to some or all of the same six proteins, there are decided differences among them in terms of their relative affinities. For example, cefoxitin (see Table 1 for structures) fails to bind to protein 2 while cephacetrile binds very slowly to proteins 5 and 6. Cephaloridine binds most avidly to protein 1, the transpeptidase, and inhibits cell elongation and causes lysis at its minimum inhibitory concentration. On the other hand, cephalexin binds preferentially to protein 3 and causes inhibition of cell division and filament formation (75PNA2999, 77MI51002). 

Activities are expressed as minimum inhibitory concentration (MIC, pg mL ) defined as the lowest concentration required for complete inhibition of growth of bacterial strain. 

Vancomycin is bactericidal to most susceptible bacteria at concentrations near its minimum inhibitory concentration (MIC) and is an inhibitor of bacterial cell wall peptidoglycan synthesis, although at a site different from that of j3-lactam antibiotics (Chapter 9). 

Table 11.2 Effect of inoculum size on the minimum inhibitory concentration (MIC) of three antiseptics against Staphylococcus aureus... 

Graded doses ofthe test substance are incorporated into broth dispensed in McCartney boules and the bottles inoculated with the test organism and incubated. The point at which no growth occurs is taken as the bacteriostatic concentration (minimum inhibitory concentration, MIC). It is essential when performing these tests to determine the size of the inoculum as the position of the end-point varies considerably with inoculum size, which should always be defined in any description of result. 

The minimum inhibitory concentration (MIC) is the lowest concentration of an antimicrobial agent that prevents growth. The lower the MIC value, the more active the agent. 

LFT, liver function tests MIC, minimum inhibitory concentration. Adapted, with permission, from ref. 14. 

LFT, liver function tests MIC, minimum inhibitory concentration. 

Infective endocarditis caused by these streptococci typically has a subacute clinical course. The current cure rate is often over 90% unless complications occur, which is the case in more than 30% of patients.17 The majority of viridans streptococci remain very susceptible to penicillin, with most strains having a minimum inhibitory concentration (MIC) of less than 0.125 mcg/mL.15,18 Organisms with decreased susceptibilities are increasing. Therefore, antibiotic susceptibilities need to be assessed in order to determine the most appropriate treatment regimen. 

Minimum inhibitory concentration less than or equal to 0.1 2 mcg/mL. 

Penicillin C 24 million units/24 hours IV in 4 to 6 equally divided doses may be used in place of nafcillin or oxacillin if strain is penicillin-susceptible (minimum inhibitory concentration less than or equal to 0.1 mcg/mL) and does not produce P-lactamase. cGentamicin should be administered in close temporal proximity to vancomycin, nafcillin, or oxacillin dosing. 

IVDUs intravenous drug users MIC minimum inhibitory concentration... 

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