Minimum inhibitory concentration MIC

Table 1. Minimum Inhibitory Concentration (MIC) of Chloramphenicol and Thiamphenicol Against Sensitive Organisms...

Table 5. Minimum Inhibitory Concentrations (MIC q ) of Florfenicol (2) and Other Antibiotics Against Bacterial Pathogens Isolated from Fish in Japan, Jg/mL...

Activities are expressed as minimum inhibitory concentration (MIC, pg mL ) defined as the lowest concentration required for complete inhibition of growth of bacterial strain. 

Vancomycin is bactericidal to most susceptible bacteria at concentrations near its minimum inhibitory concentration (MIC) and is an inhibitor of bacterial cell wall peptidoglycan synthesis, although at a site different from that of j3-lactam antibiotics (Chapter 9). 

Table 11.2 Effect of inoculum size on the minimum inhibitory concentration (MIC) of three antiseptics against Staphylococcus aureus... 

Graded doses ofthe test substance are incorporated into broth dispensed in McCartney boules and the bottles inoculated with the test organism and incubated. The point at which no growth occurs is taken as the bacteriostatic concentration (minimum inhibitory concentration, MIC). It is essential when performing these tests to determine the size of the inoculum as the position of the end-point varies considerably with inoculum size, which should always be defined in any description of result. 

The minimum inhibitory concentration (MIC) is the lowest concentration of an antimicrobial agent that prevents growth. The lower the MIC value, the more active the agent. 

Infective endocarditis caused by these streptococci typically has a subacute clinical course. The current cure rate is often over 90% unless complications occur, which is the case in more than 30% of patients.17 The majority of viridans streptococci remain very susceptible to penicillin, with most strains having a minimum inhibitory concentration (MIC) of less than 0.125 mcg/mL.15,18 Organisms with decreased susceptibilities are increasing. Therefore, antibiotic susceptibilities need to be assessed in order to determine the most appropriate treatment regimen. 

Pharmacokinetic parameters such as area under the concentration-time curve (AUC) and maximal plasma concentration can be predictive of treatment outcome when specific ratios of AUC or maximal plasma concentration to the minimum inhibitory concentration (MIC) are achieved. For... 

Minimum inhibitory concentration (MIC) greater than 0.12 mcg/mL to less than or equal to 0.5 mcg/mL. 

Antibiotic concentrations in respiratory secretions in excess of the pathogen minimum inhibitory concentration (MIC) are necessary for successful treatment of pulmonary infections. 

Organisms may be considered susceptible if the Minimum Inhibitory Concentration (MIC) is not more than 4.0 yg/ml and intermediate if the MIC is 4.0-12.5 yg/ml (see Table 1). Tetracyclines are readily absorbed and are bound to plasma proteins in varying degrees. They are concentrated by the liver in the bile and excreted in the urine and feces at high concentrations and in a biologically active form. 

Compound 11 showed AChE inhibitory activity with an ICj, 19 pM. and weak antifimgal activity against Candida albicans with a minimum inhibitory concentration (MIC) value of 23 pg/ml. 

The microdilution method was employed for antibacterial and antifungal activity tests. Media were placed into each well of the 96 well-microplate. Extract solutions at 1,024 pg/ml were added into first raw of microplates and twofold dilutions of the compounds (512-0.25 pg/ml) were made by dispensing the solutions to the remaining wells. Ten microliters of culture suspensions were inoculated into all the wells. The sealed microplates were incubated at 35°C for 24 and 48 h in humid chamber. The lowest concentration of the extracts that completely inhibit macroscopic growth was determined and minimum inhibitory concentrations (MICs) were... 

Table 8.4 Antibacterial and antifungal activities of the LC extracts as minimum inhibitory concentrations (MICs)(ng/ml)... 

Fig. 2. Example of rough activity landscape. This figure shows the activity landscape for a series of related antibacterial compounds plotted in using the 2D BCUT descriptors to arrange the compounds. (A) Shows how the compounds are arrayed in a 2D representation of the chemistry space with the height of the marker being proportional to the minimum inhibitor concentration of the compounds [the smaller the minimum inhibitory concentration (MIC) the more potent the compound]. (B) This second panel presents the upper figure as a 2D figure to enhance the sharp cutoff between active and inactive compounds, emphasizing the point that activity landscapes are rarely smooth continuous functions.

Table 1 Minimum Inhibitory Concentrations (MIC) of Bronopol against Gram negative and positive bacteria...

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