Microspheres drug targeting

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El-Shafy, M. A., Kellaway, I. W., Taylor, G, and Dickinson, P. A. (2000), Improved nasal bioavailability of FITC-dextran (Mw 4300) from mucoadhesive microspheres in rabbits, J. Drug Target., 7, 355-361. 

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Menei P, Benoit JP, Boisdron-Celle M, Fournier D, Mercier P, Guy G. Drug targeting into the central nervous system by stereotactic implantation of biodegradable microspheres. Neurosurgery 1994 34 1058—1064. 

Jepson, M.A., Simmons, N.L., Hagan, D.T.O., Hirst, B.H. Comparison of poly(DL-lactide-co-glycolide) and polystyrene microsphere targeting to intestinal M cells. J. Drug Target., 1, 245, 1993. 

Patashnik, S., Rabinovich, L., Golomb, G. (1997). Preparation and evaluation of chitosan microspheres containing bisphosphonates, 1. Drug Target. 4(6), 371-380. 

Ma, X.H., Santiago, N., Chen, Y.S., Chaudhary, K., Milstein, S.J., and Baughman, R.A., Stability study of dmg-loaded proteinoid microsphere formulations during freeze-drying, J. Drug Target., 1994, 2, 9-21. 

Drugs, cosmetic ingredients, and food additives are microencapsulated for a variety of reasons, which include reducing local side-effects, controlled release, site-specific (drug) delivery, and drug targeting. A tremendous amount of research work has been done in a search for suitable methods to achieve an effective eneapsulation of water-soluble active matter. The physical characteristics of the microspheres produced largely determine their suitability for use for different objectives. Microspheres are prepared from both natural and synthetic polymers. 

Khan, A. et al.. Site-specific administration of antisense oligonucleotides using biodegradable polymer microspheres provides sustained delivery and improved subcellular biodistribution in the neostriatum of the rat brain, /. Drug Target, 8,319,2000. 

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